THE MECHANISM OF THE INHIBITION OF HEMOLYSIS : II. EFFECTS OF pH ON INHIBITION BY PLASMA AND BY CHOLESTEROL SOLS

The effects of variations of pH, from 5.6 to 8.6, on the lytic activity of saponin, digitonin, and sodium taurocholate, and the effects on the inhibition produced by plasma and by cholesterol sols, are described. The results, so far as they can be analyzed, show that the pH dependence of the inhibit...

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Autor principal: Ponder, Eric
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1945
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2142671/
https://www.ncbi.nlm.nih.gov/pubmed/19873425
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author Ponder, Eric
author_facet Ponder, Eric
author_sort Ponder, Eric
collection PubMed
description The effects of variations of pH, from 5.6 to 8.6, on the lytic activity of saponin, digitonin, and sodium taurocholate, and the effects on the inhibition produced by plasma and by cholesterol sols, are described. The results, so far as they can be analyzed, show that the pH dependence of the inhibition produced by plasma is different from that of the inhibition produced by cholesterol sols, and this leads to the conclusion that a considerable part of the inhibition produced by plasma is due to inhibitory substances other than cholesterol. The results also provide a certain amount of indirect evidence that hemolysis is not due primarily to a reaction of the lysins with the cholesterol of the red cell membrane.
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spelling pubmed-21426712008-04-23 THE MECHANISM OF THE INHIBITION OF HEMOLYSIS : II. EFFECTS OF pH ON INHIBITION BY PLASMA AND BY CHOLESTEROL SOLS Ponder, Eric J Gen Physiol Article The effects of variations of pH, from 5.6 to 8.6, on the lytic activity of saponin, digitonin, and sodium taurocholate, and the effects on the inhibition produced by plasma and by cholesterol sols, are described. The results, so far as they can be analyzed, show that the pH dependence of the inhibition produced by plasma is different from that of the inhibition produced by cholesterol sols, and this leads to the conclusion that a considerable part of the inhibition produced by plasma is due to inhibitory substances other than cholesterol. The results also provide a certain amount of indirect evidence that hemolysis is not due primarily to a reaction of the lysins with the cholesterol of the red cell membrane. The Rockefeller University Press 1945-03-20 /pmc/articles/PMC2142671/ /pubmed/19873425 Text en Copyright © Copyright, 1945, by The Rockefeller Institute for Medical Research This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Ponder, Eric
THE MECHANISM OF THE INHIBITION OF HEMOLYSIS : II. EFFECTS OF pH ON INHIBITION BY PLASMA AND BY CHOLESTEROL SOLS
title THE MECHANISM OF THE INHIBITION OF HEMOLYSIS : II. EFFECTS OF pH ON INHIBITION BY PLASMA AND BY CHOLESTEROL SOLS
title_full THE MECHANISM OF THE INHIBITION OF HEMOLYSIS : II. EFFECTS OF pH ON INHIBITION BY PLASMA AND BY CHOLESTEROL SOLS
title_fullStr THE MECHANISM OF THE INHIBITION OF HEMOLYSIS : II. EFFECTS OF pH ON INHIBITION BY PLASMA AND BY CHOLESTEROL SOLS
title_full_unstemmed THE MECHANISM OF THE INHIBITION OF HEMOLYSIS : II. EFFECTS OF pH ON INHIBITION BY PLASMA AND BY CHOLESTEROL SOLS
title_short THE MECHANISM OF THE INHIBITION OF HEMOLYSIS : II. EFFECTS OF pH ON INHIBITION BY PLASMA AND BY CHOLESTEROL SOLS
title_sort mechanism of the inhibition of hemolysis : ii. effects of ph on inhibition by plasma and by cholesterol sols
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2142671/
https://www.ncbi.nlm.nih.gov/pubmed/19873425
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