STUDIES ON A NEW METABOLITE AND ITS OXIDATION IN THE PRESENCE OF ASCORBIC ACID

1. A number of tissues, in particular, brain, liver, and kidney, incubated aerobically in vitro as slices or ground suspensions produce a compound which combines with p-aminobenzoic acid in acid solution to form a yellow color. 2. A study of this reaction in rat brain has shown that this compound ca...

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Detalles Bibliográficos
Autores principales: Bernheim, Frederick, Wilbur, Karl M., Fitzgerald, Dorothea B.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1947
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147095/
https://www.ncbi.nlm.nih.gov/pubmed/18896940
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author Bernheim, Frederick
Wilbur, Karl M.
Fitzgerald, Dorothea B.
author_facet Bernheim, Frederick
Wilbur, Karl M.
Fitzgerald, Dorothea B.
author_sort Bernheim, Frederick
collection PubMed
description 1. A number of tissues, in particular, brain, liver, and kidney, incubated aerobically in vitro as slices or ground suspensions produce a compound which combines with p-aminobenzoic acid in acid solution to form a yellow color. 2. A study of this reaction in rat brain has shown that this compound can be produced when washed boiled brain protein is incubated aerobically with ascorbic acid. The latter acts as a catalyst to break the linkage between the protein and the compound. Oxygen is taken up in the process. 3. A number of aromatic hydroxy compounds such as epinephrine and catechol inhibit the reaction. Cyanide has little or no effect. No reaction occurs anaerobically. 4. The occurrence of the reaction in some animals has been described.
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spelling pubmed-21470952008-04-23 STUDIES ON A NEW METABOLITE AND ITS OXIDATION IN THE PRESENCE OF ASCORBIC ACID Bernheim, Frederick Wilbur, Karl M. Fitzgerald, Dorothea B. J Gen Physiol Article 1. A number of tissues, in particular, brain, liver, and kidney, incubated aerobically in vitro as slices or ground suspensions produce a compound which combines with p-aminobenzoic acid in acid solution to form a yellow color. 2. A study of this reaction in rat brain has shown that this compound can be produced when washed boiled brain protein is incubated aerobically with ascorbic acid. The latter acts as a catalyst to break the linkage between the protein and the compound. Oxygen is taken up in the process. 3. A number of aromatic hydroxy compounds such as epinephrine and catechol inhibit the reaction. Cyanide has little or no effect. No reaction occurs anaerobically. 4. The occurrence of the reaction in some animals has been described. The Rockefeller University Press 1947-11-20 /pmc/articles/PMC2147095/ /pubmed/18896940 Text en Copyright © Copyright, 1947, by The Rockefeller Institute for Medical Research This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Bernheim, Frederick
Wilbur, Karl M.
Fitzgerald, Dorothea B.
STUDIES ON A NEW METABOLITE AND ITS OXIDATION IN THE PRESENCE OF ASCORBIC ACID
title STUDIES ON A NEW METABOLITE AND ITS OXIDATION IN THE PRESENCE OF ASCORBIC ACID
title_full STUDIES ON A NEW METABOLITE AND ITS OXIDATION IN THE PRESENCE OF ASCORBIC ACID
title_fullStr STUDIES ON A NEW METABOLITE AND ITS OXIDATION IN THE PRESENCE OF ASCORBIC ACID
title_full_unstemmed STUDIES ON A NEW METABOLITE AND ITS OXIDATION IN THE PRESENCE OF ASCORBIC ACID
title_short STUDIES ON A NEW METABOLITE AND ITS OXIDATION IN THE PRESENCE OF ASCORBIC ACID
title_sort studies on a new metabolite and its oxidation in the presence of ascorbic acid
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147095/
https://www.ncbi.nlm.nih.gov/pubmed/18896940
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AT wilburkarlm studiesonanewmetaboliteanditsoxidationinthepresenceofascorbicacid
AT fitzgeralddorotheab studiesonanewmetaboliteanditsoxidationinthepresenceofascorbicacid

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