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ON THE MUTATION OF THE TOBACCO MOSAIC VIRUS
Experiments on x-ray-induced mutations of the tobacco mosaic virus (Gowen) are analyzed on the basis of the ionization theory. The size of the volume within which the primary process of mutation develops is calculated on the basis of three alternative assumptions; viz., (1) that this volume consists...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1949
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147145/ https://www.ncbi.nlm.nih.gov/pubmed/15392565 |
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author | Opatowski, I. |
author_facet | Opatowski, I. |
author_sort | Opatowski, I. |
collection | PubMed |
description | Experiments on x-ray-induced mutations of the tobacco mosaic virus (Gowen) are analyzed on the basis of the ionization theory. The size of the volume within which the primary process of mutation develops is calculated on the basis of three alternative assumptions; viz., (1) that this volume consists of protein, (2) that it is nucleic acid, (3) that it is phosphorus. It is found that the volume calculated under assumption (1) is identical with the hexagonal cell unit which Bernal and Fankuchen found in the virus protein by x-ray diffraction. Assumptions 2 and 3 lead respectively to the conclusions that one-fourth of the total nucleic acid content or one-half of the total phosphorus content is involved in the mutational process. The relation between the induced and the spontaneous mutation is examined and it is found that natural ionizing radiations are completely insignificant for the spontaneous mutation of the virus. |
format | Text |
id | pubmed-2147145 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1949 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21471452008-04-23 ON THE MUTATION OF THE TOBACCO MOSAIC VIRUS Opatowski, I. J Gen Physiol Article Experiments on x-ray-induced mutations of the tobacco mosaic virus (Gowen) are analyzed on the basis of the ionization theory. The size of the volume within which the primary process of mutation develops is calculated on the basis of three alternative assumptions; viz., (1) that this volume consists of protein, (2) that it is nucleic acid, (3) that it is phosphorus. It is found that the volume calculated under assumption (1) is identical with the hexagonal cell unit which Bernal and Fankuchen found in the virus protein by x-ray diffraction. Assumptions 2 and 3 lead respectively to the conclusions that one-fourth of the total nucleic acid content or one-half of the total phosphorus content is involved in the mutational process. The relation between the induced and the spontaneous mutation is examined and it is found that natural ionizing radiations are completely insignificant for the spontaneous mutation of the virus. The Rockefeller University Press 1949-11-20 /pmc/articles/PMC2147145/ /pubmed/15392565 Text en Copyright © Copyright, 1949, by The Rockefeller Institute for Medical Research This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Opatowski, I. ON THE MUTATION OF THE TOBACCO MOSAIC VIRUS |
title | ON THE MUTATION OF THE TOBACCO MOSAIC VIRUS |
title_full | ON THE MUTATION OF THE TOBACCO MOSAIC VIRUS |
title_fullStr | ON THE MUTATION OF THE TOBACCO MOSAIC VIRUS |
title_full_unstemmed | ON THE MUTATION OF THE TOBACCO MOSAIC VIRUS |
title_short | ON THE MUTATION OF THE TOBACCO MOSAIC VIRUS |
title_sort | on the mutation of the tobacco mosaic virus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147145/ https://www.ncbi.nlm.nih.gov/pubmed/15392565 |
work_keys_str_mv | AT opatowskii onthemutationofthetobaccomosaicvirus |