TISSUE CULTURE STUDIES : III. THE RELATIONSHIP OF INCORPORATION OF RADIOACTIVE PHOSPHORUS IN NUCLEIC ACID TO THE GROWTH OF CELLS IN VITRO

Growing cultures are shown to incorporate more radioactive phosphorus into ribo- and desoxyribonucleic acid than non-growing cultures. Strong indications are found that the incorporation of inorganic phosphorus into desoxyribonucleic acid parallels the mitotic coefficient and serves as a sensitive i...

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Detalles Bibliográficos
Autores principales: Hull, Wayne, Kirk, Paul L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1950
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147194/
https://www.ncbi.nlm.nih.gov/pubmed/15406371
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author Hull, Wayne
Kirk, Paul L.
author_facet Hull, Wayne
Kirk, Paul L.
author_sort Hull, Wayne
collection PubMed
description Growing cultures are shown to incorporate more radioactive phosphorus into ribo- and desoxyribonucleic acid than non-growing cultures. Strong indications are found that the incorporation of inorganic phosphorus into desoxyribonucleic acid parallels the mitotic coefficient and serves as a sensitive index of synthesis of new cells. There are indications that the phosphorus compounds from which the DNA molecule was synthesized were in equilibrium with the inorganic phosphorus of the medium. The effect of the implant upon growth of new cells and the assay of growth is discussed. Metabolic turnover was increased in adequate medium.
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spelling pubmed-21471942008-04-23 TISSUE CULTURE STUDIES : III. THE RELATIONSHIP OF INCORPORATION OF RADIOACTIVE PHOSPHORUS IN NUCLEIC ACID TO THE GROWTH OF CELLS IN VITRO Hull, Wayne Kirk, Paul L. J Gen Physiol Article Growing cultures are shown to incorporate more radioactive phosphorus into ribo- and desoxyribonucleic acid than non-growing cultures. Strong indications are found that the incorporation of inorganic phosphorus into desoxyribonucleic acid parallels the mitotic coefficient and serves as a sensitive index of synthesis of new cells. There are indications that the phosphorus compounds from which the DNA molecule was synthesized were in equilibrium with the inorganic phosphorus of the medium. The effect of the implant upon growth of new cells and the assay of growth is discussed. Metabolic turnover was increased in adequate medium. The Rockefeller University Press 1950-03-20 /pmc/articles/PMC2147194/ /pubmed/15406371 Text en Copyright © Copyright, 1950, by The Rockefeller Institute for Medical Research This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Hull, Wayne
Kirk, Paul L.
TISSUE CULTURE STUDIES : III. THE RELATIONSHIP OF INCORPORATION OF RADIOACTIVE PHOSPHORUS IN NUCLEIC ACID TO THE GROWTH OF CELLS IN VITRO
title TISSUE CULTURE STUDIES : III. THE RELATIONSHIP OF INCORPORATION OF RADIOACTIVE PHOSPHORUS IN NUCLEIC ACID TO THE GROWTH OF CELLS IN VITRO
title_full TISSUE CULTURE STUDIES : III. THE RELATIONSHIP OF INCORPORATION OF RADIOACTIVE PHOSPHORUS IN NUCLEIC ACID TO THE GROWTH OF CELLS IN VITRO
title_fullStr TISSUE CULTURE STUDIES : III. THE RELATIONSHIP OF INCORPORATION OF RADIOACTIVE PHOSPHORUS IN NUCLEIC ACID TO THE GROWTH OF CELLS IN VITRO
title_full_unstemmed TISSUE CULTURE STUDIES : III. THE RELATIONSHIP OF INCORPORATION OF RADIOACTIVE PHOSPHORUS IN NUCLEIC ACID TO THE GROWTH OF CELLS IN VITRO
title_short TISSUE CULTURE STUDIES : III. THE RELATIONSHIP OF INCORPORATION OF RADIOACTIVE PHOSPHORUS IN NUCLEIC ACID TO THE GROWTH OF CELLS IN VITRO
title_sort tissue culture studies : iii. the relationship of incorporation of radioactive phosphorus in nucleic acid to the growth of cells in vitro
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147194/
https://www.ncbi.nlm.nih.gov/pubmed/15406371
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