THE INTRINSIC VISCOSITY OF MIXED PROTEIN SYSTEMS, INCLUDING STUDIES OF PLASMA AND SERUM

Experimental evidence is presented that the intrinsic viscosity of solutions of mixed proteins obeys the additive equation See PDF for Equation. The datum serves to characterize the system, and combined with other analytical techniques and fractionation procedures, enables one to analyze and charact...

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Detalles Bibliográficos
Autores principales: Hess, Eugene L., Cobure, Aspascia
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1950
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147209/
https://www.ncbi.nlm.nih.gov/pubmed/15422105
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author Hess, Eugene L.
Cobure, Aspascia
author_facet Hess, Eugene L.
Cobure, Aspascia
author_sort Hess, Eugene L.
collection PubMed
description Experimental evidence is presented that the intrinsic viscosity of solutions of mixed proteins obeys the additive equation See PDF for Equation. The datum serves to characterize the system, and combined with other analytical techniques and fractionation procedures, enables one to analyze and characterize subfractions. The plasmas and sera of clinically "normal" individuals give intrinsic viscosity values agreeing with calculated values. The intrinsic viscosity values for pathological plasmas and sera in all cases are greater than normal and reflect the augmented levels of those proteins fibrinogen, α(2)-globulins, and γ-globulins occurring in the pathological state. The method is readily adaptable to routine clinical use and furnishes a measure of the departure from normal of protein levels in serum and plasma.
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spelling pubmed-21472092008-04-23 THE INTRINSIC VISCOSITY OF MIXED PROTEIN SYSTEMS, INCLUDING STUDIES OF PLASMA AND SERUM Hess, Eugene L. Cobure, Aspascia J Gen Physiol Article Experimental evidence is presented that the intrinsic viscosity of solutions of mixed proteins obeys the additive equation See PDF for Equation. The datum serves to characterize the system, and combined with other analytical techniques and fractionation procedures, enables one to analyze and characterize subfractions. The plasmas and sera of clinically "normal" individuals give intrinsic viscosity values agreeing with calculated values. The intrinsic viscosity values for pathological plasmas and sera in all cases are greater than normal and reflect the augmented levels of those proteins fibrinogen, α(2)-globulins, and γ-globulins occurring in the pathological state. The method is readily adaptable to routine clinical use and furnishes a measure of the departure from normal of protein levels in serum and plasma. The Rockefeller University Press 1950-05-20 /pmc/articles/PMC2147209/ /pubmed/15422105 Text en Copyright © Copyright, 1950, by The Rockefeller Institute for Medical Research This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Hess, Eugene L.
Cobure, Aspascia
THE INTRINSIC VISCOSITY OF MIXED PROTEIN SYSTEMS, INCLUDING STUDIES OF PLASMA AND SERUM
title THE INTRINSIC VISCOSITY OF MIXED PROTEIN SYSTEMS, INCLUDING STUDIES OF PLASMA AND SERUM
title_full THE INTRINSIC VISCOSITY OF MIXED PROTEIN SYSTEMS, INCLUDING STUDIES OF PLASMA AND SERUM
title_fullStr THE INTRINSIC VISCOSITY OF MIXED PROTEIN SYSTEMS, INCLUDING STUDIES OF PLASMA AND SERUM
title_full_unstemmed THE INTRINSIC VISCOSITY OF MIXED PROTEIN SYSTEMS, INCLUDING STUDIES OF PLASMA AND SERUM
title_short THE INTRINSIC VISCOSITY OF MIXED PROTEIN SYSTEMS, INCLUDING STUDIES OF PLASMA AND SERUM
title_sort intrinsic viscosity of mixed protein systems, including studies of plasma and serum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147209/
https://www.ncbi.nlm.nih.gov/pubmed/15422105
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