POLYPLOIDY AND CANCER : THE DESOXYPENTOSENUCLEIC ACID CONTENT OF NUCLEI OF NORMAL, PRECANCEROUS, AND NEOPLASTIC RAT TISSUES

The average desoxypentosenucleic acid content of individual nuclei was determined for various normal and tumor tissues, and for livers showing precancerous changes, in the rat. With certain exceptions attributable to polyploidy, the values were practically indistinguishable from each other and from...

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Detalles Bibliográficos
Autores principales: Cunningham, Lew, Griffin, A. Clark, Luck, J. Murray
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1950
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147238/
https://www.ncbi.nlm.nih.gov/pubmed/14778978
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author Cunningham, Lew
Griffin, A. Clark
Luck, J. Murray
author_facet Cunningham, Lew
Griffin, A. Clark
Luck, J. Murray
author_sort Cunningham, Lew
collection PubMed
description The average desoxypentosenucleic acid content of individual nuclei was determined for various normal and tumor tissues, and for livers showing precancerous changes, in the rat. With certain exceptions attributable to polyploidy, the values were practically indistinguishable from each other and from values reported for cell nuclei of other mammals. The amount of this nucleic acid in diploid cells of the rat appears to be a constant, nearly equal to 6 x 10(–6) micrograms. Findings of increased concentrations of this nucleic acid in tissues showing preneoplastic or neoplastic changes therefore confirm histological observations of increased cellularity and polyploidy in such tissues.
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spelling pubmed-21472382008-04-23 POLYPLOIDY AND CANCER : THE DESOXYPENTOSENUCLEIC ACID CONTENT OF NUCLEI OF NORMAL, PRECANCEROUS, AND NEOPLASTIC RAT TISSUES Cunningham, Lew Griffin, A. Clark Luck, J. Murray J Gen Physiol Article The average desoxypentosenucleic acid content of individual nuclei was determined for various normal and tumor tissues, and for livers showing precancerous changes, in the rat. With certain exceptions attributable to polyploidy, the values were practically indistinguishable from each other and from values reported for cell nuclei of other mammals. The amount of this nucleic acid in diploid cells of the rat appears to be a constant, nearly equal to 6 x 10(–6) micrograms. Findings of increased concentrations of this nucleic acid in tissues showing preneoplastic or neoplastic changes therefore confirm histological observations of increased cellularity and polyploidy in such tissues. The Rockefeller University Press 1950-09-20 /pmc/articles/PMC2147238/ /pubmed/14778978 Text en Copyright © Copyright, 1950, by The Rockefeller Institute for Medical Research This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Cunningham, Lew
Griffin, A. Clark
Luck, J. Murray
POLYPLOIDY AND CANCER : THE DESOXYPENTOSENUCLEIC ACID CONTENT OF NUCLEI OF NORMAL, PRECANCEROUS, AND NEOPLASTIC RAT TISSUES
title POLYPLOIDY AND CANCER : THE DESOXYPENTOSENUCLEIC ACID CONTENT OF NUCLEI OF NORMAL, PRECANCEROUS, AND NEOPLASTIC RAT TISSUES
title_full POLYPLOIDY AND CANCER : THE DESOXYPENTOSENUCLEIC ACID CONTENT OF NUCLEI OF NORMAL, PRECANCEROUS, AND NEOPLASTIC RAT TISSUES
title_fullStr POLYPLOIDY AND CANCER : THE DESOXYPENTOSENUCLEIC ACID CONTENT OF NUCLEI OF NORMAL, PRECANCEROUS, AND NEOPLASTIC RAT TISSUES
title_full_unstemmed POLYPLOIDY AND CANCER : THE DESOXYPENTOSENUCLEIC ACID CONTENT OF NUCLEI OF NORMAL, PRECANCEROUS, AND NEOPLASTIC RAT TISSUES
title_short POLYPLOIDY AND CANCER : THE DESOXYPENTOSENUCLEIC ACID CONTENT OF NUCLEI OF NORMAL, PRECANCEROUS, AND NEOPLASTIC RAT TISSUES
title_sort polyploidy and cancer : the desoxypentosenucleic acid content of nuclei of normal, precancerous, and neoplastic rat tissues
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147238/
https://www.ncbi.nlm.nih.gov/pubmed/14778978
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