THE SIGNIFICANCE OF REGRESSION LINE SLOPE CHANGES IN THE QUANTITATIVE TITRATION OF COMPLEMENT COMPONENTS

The hypothesis is discussed that dissociable complexes are formed between elements of a test complement (C') and the reagent used to titrate it for a particular component. Calculations are presented which demonstrate that such complex formation may give considerable changes in slopes of percent...

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Detalles Bibliográficos
Autor principal: Waksman, Byron H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1950
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147242/
https://www.ncbi.nlm.nih.gov/pubmed/14778976
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author Waksman, Byron H.
author_facet Waksman, Byron H.
author_sort Waksman, Byron H.
collection PubMed
description The hypothesis is discussed that dissociable complexes are formed between elements of a test complement (C') and the reagent used to titrate it for a particular component. Calculations are presented which demonstrate that such complex formation may give considerable changes in slopes of percentage hemolysis-log dose regression lines obtained with mixtures of C' and reagent. It is shown that marked change of slope may occur with relatively little change in the value of the 50 per cent intercept.
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spelling pubmed-21472422008-04-23 THE SIGNIFICANCE OF REGRESSION LINE SLOPE CHANGES IN THE QUANTITATIVE TITRATION OF COMPLEMENT COMPONENTS Waksman, Byron H. J Gen Physiol Article The hypothesis is discussed that dissociable complexes are formed between elements of a test complement (C') and the reagent used to titrate it for a particular component. Calculations are presented which demonstrate that such complex formation may give considerable changes in slopes of percentage hemolysis-log dose regression lines obtained with mixtures of C' and reagent. It is shown that marked change of slope may occur with relatively little change in the value of the 50 per cent intercept. The Rockefeller University Press 1950-09-20 /pmc/articles/PMC2147242/ /pubmed/14778976 Text en Copyright © Copyright, 1950, by The Rockefeller Institute for Medical Research This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Waksman, Byron H.
THE SIGNIFICANCE OF REGRESSION LINE SLOPE CHANGES IN THE QUANTITATIVE TITRATION OF COMPLEMENT COMPONENTS
title THE SIGNIFICANCE OF REGRESSION LINE SLOPE CHANGES IN THE QUANTITATIVE TITRATION OF COMPLEMENT COMPONENTS
title_full THE SIGNIFICANCE OF REGRESSION LINE SLOPE CHANGES IN THE QUANTITATIVE TITRATION OF COMPLEMENT COMPONENTS
title_fullStr THE SIGNIFICANCE OF REGRESSION LINE SLOPE CHANGES IN THE QUANTITATIVE TITRATION OF COMPLEMENT COMPONENTS
title_full_unstemmed THE SIGNIFICANCE OF REGRESSION LINE SLOPE CHANGES IN THE QUANTITATIVE TITRATION OF COMPLEMENT COMPONENTS
title_short THE SIGNIFICANCE OF REGRESSION LINE SLOPE CHANGES IN THE QUANTITATIVE TITRATION OF COMPLEMENT COMPONENTS
title_sort significance of regression line slope changes in the quantitative titration of complement components
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147242/
https://www.ncbi.nlm.nih.gov/pubmed/14778976
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