TISSUE CULTURE STUDIES : V. ANALOGUES FOR NICOTINIC ACID

The use of acetyl-3-pyridine and pyridine-3-sulfonic acid as analogues for nicotinic acid has been tested with tissue cultures of embryonic chick heart. Both roller tube and Carrel flask cultures were employed. Cell migration, appearance of the cells, and the uptake of tracer P(32) were used as crit...

Descripción completa

Detalles Bibliográficos
Autores principales: Hull, Wayne, Perrone, J. C., Kirk, Paul L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1950
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147245/
https://www.ncbi.nlm.nih.gov/pubmed/14778980
_version_ 1782144394243080192
author Hull, Wayne
Perrone, J. C.
Kirk, Paul L.
author_facet Hull, Wayne
Perrone, J. C.
Kirk, Paul L.
author_sort Hull, Wayne
collection PubMed
description The use of acetyl-3-pyridine and pyridine-3-sulfonic acid as analogues for nicotinic acid has been tested with tissue cultures of embryonic chick heart. Both roller tube and Carrel flask cultures were employed. Cell migration, appearance of the cells, and the uptake of tracer P(32) were used as criteria for the action of the analogues. Migration of the cells could be inhibited by both compounds, but at different levels. Both produced abnormal types of cells, but not the same type of abnormality. Uptake of P(32) was inhibited by both compounds. Addition of nicotinic acid failed to reverse the effects of the analogues at the concentrations used.
format Text
id pubmed-2147245
institution National Center for Biotechnology Information
language English
publishDate 1950
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21472452008-04-23 TISSUE CULTURE STUDIES : V. ANALOGUES FOR NICOTINIC ACID Hull, Wayne Perrone, J. C. Kirk, Paul L. J Gen Physiol Article The use of acetyl-3-pyridine and pyridine-3-sulfonic acid as analogues for nicotinic acid has been tested with tissue cultures of embryonic chick heart. Both roller tube and Carrel flask cultures were employed. Cell migration, appearance of the cells, and the uptake of tracer P(32) were used as criteria for the action of the analogues. Migration of the cells could be inhibited by both compounds, but at different levels. Both produced abnormal types of cells, but not the same type of abnormality. Uptake of P(32) was inhibited by both compounds. Addition of nicotinic acid failed to reverse the effects of the analogues at the concentrations used. The Rockefeller University Press 1950-09-20 /pmc/articles/PMC2147245/ /pubmed/14778980 Text en Copyright © Copyright, 1950, by The Rockefeller Institute for Medical Research This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Hull, Wayne
Perrone, J. C.
Kirk, Paul L.
TISSUE CULTURE STUDIES : V. ANALOGUES FOR NICOTINIC ACID
title TISSUE CULTURE STUDIES : V. ANALOGUES FOR NICOTINIC ACID
title_full TISSUE CULTURE STUDIES : V. ANALOGUES FOR NICOTINIC ACID
title_fullStr TISSUE CULTURE STUDIES : V. ANALOGUES FOR NICOTINIC ACID
title_full_unstemmed TISSUE CULTURE STUDIES : V. ANALOGUES FOR NICOTINIC ACID
title_short TISSUE CULTURE STUDIES : V. ANALOGUES FOR NICOTINIC ACID
title_sort tissue culture studies : v. analogues for nicotinic acid
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147245/
https://www.ncbi.nlm.nih.gov/pubmed/14778980
work_keys_str_mv AT hullwayne tissueculturestudiesvanaloguesfornicotinicacid
AT perronejc tissueculturestudiesvanaloguesfornicotinicacid
AT kirkpaull tissueculturestudiesvanaloguesfornicotinicacid

Ejemplares similares