Cargando…
THE METAMORPHOSIS OF HEMOGLOBIN IN THE BULLFROG
1. Tadpole and adult hemoglobin do not differ significantly in molecular weight. The molecular weight of both is in the neighborhood of 68,000. 2. Heme-heme interaction as measured by the value of n in Hill's equation is virtually the same—about 2.8—in both tadpole and adult. 3. There appears t...
Autor principal: | |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1951
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147295/ https://www.ncbi.nlm.nih.gov/pubmed/14873918 |
_version_ | 1782144405818310656 |
---|---|
author | Riggs, Austen |
author_facet | Riggs, Austen |
author_sort | Riggs, Austen |
collection | PubMed |
description | 1. Tadpole and adult hemoglobin do not differ significantly in molecular weight. The molecular weight of both is in the neighborhood of 68,000. 2. Heme-heme interaction as measured by the value of n in Hill's equation is virtually the same—about 2.8—in both tadpole and adult. 3. There appears to be no significant effect of pH upon the oxygen equilibrium of tadpole hemoglobin, in contrast to large Bohr and reverse Bohr effects in the adult. This is taken to mean that during metamorphosis acid groups of globin become sensitive to the oxygenation of heme by some change in the mode of linkage between heme and globin. 4. The oxygen affinity of tadpole hemoglobin is about seven times as great as that of the adult at pH 6 and twice as great at pH 9. |
format | Text |
id | pubmed-2147295 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1951 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21472952008-04-23 THE METAMORPHOSIS OF HEMOGLOBIN IN THE BULLFROG Riggs, Austen J Gen Physiol Article 1. Tadpole and adult hemoglobin do not differ significantly in molecular weight. The molecular weight of both is in the neighborhood of 68,000. 2. Heme-heme interaction as measured by the value of n in Hill's equation is virtually the same—about 2.8—in both tadpole and adult. 3. There appears to be no significant effect of pH upon the oxygen equilibrium of tadpole hemoglobin, in contrast to large Bohr and reverse Bohr effects in the adult. This is taken to mean that during metamorphosis acid groups of globin become sensitive to the oxygenation of heme by some change in the mode of linkage between heme and globin. 4. The oxygen affinity of tadpole hemoglobin is about seven times as great as that of the adult at pH 6 and twice as great at pH 9. The Rockefeller University Press 1951-09-20 /pmc/articles/PMC2147295/ /pubmed/14873918 Text en Copyright © Copyright, 1951, by The Rockefeller Institute for Medical Research This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Riggs, Austen THE METAMORPHOSIS OF HEMOGLOBIN IN THE BULLFROG |
title | THE METAMORPHOSIS OF HEMOGLOBIN IN THE BULLFROG |
title_full | THE METAMORPHOSIS OF HEMOGLOBIN IN THE BULLFROG |
title_fullStr | THE METAMORPHOSIS OF HEMOGLOBIN IN THE BULLFROG |
title_full_unstemmed | THE METAMORPHOSIS OF HEMOGLOBIN IN THE BULLFROG |
title_short | THE METAMORPHOSIS OF HEMOGLOBIN IN THE BULLFROG |
title_sort | metamorphosis of hemoglobin in the bullfrog |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147295/ https://www.ncbi.nlm.nih.gov/pubmed/14873918 |
work_keys_str_mv | AT riggsausten themetamorphosisofhemoglobininthebullfrog AT riggsausten metamorphosisofhemoglobininthebullfrog |