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THE SPECIFIC HEAT AND THE HEAT OF COMPRESSION OF HUMAN RED CELLS, SICKLED RED CELLS, AND PARACRYSTALLINE RAT RED CELLS
The investigation of two thermal properties of red cells throws some light on whether sickling is a process involving the crystallization of a relatively insoluble hemoglobin. These properties are the specific heat and the heat of compression, both of which would be expected to become numerically le...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1955
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147504/ https://www.ncbi.nlm.nih.gov/pubmed/14367773 |
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author | Ponder, Eric |
author_facet | Ponder, Eric |
author_sort | Ponder, Eric |
collection | PubMed |
description | The investigation of two thermal properties of red cells throws some light on whether sickling is a process involving the crystallization of a relatively insoluble hemoglobin. These properties are the specific heat and the heat of compression, both of which would be expected to become numerically less if the hemoglobin of the red cell were to crystallize. In the case of paracrystalline rat red cells, which give spacings at 45 A and 58 A by x-ray diffraction, the specific heat is reduced to 85 per cent of that of the normal red cells, and the heat of compression is only about 75 per cent of that found for the normal red cell. In the case of the red cell sickled by a reduction of the O(2) tension, the specific heat and the heat of compression are substantially the same as found for the normal red cell. This is an argument against sickling being the result of a crystallization process, and supports the observation that sickled cells do not give x-ray spacings. The result is compatible, on the other hand, with sickling being the result of the formation of an oriented and birefringent gel. |
format | Text |
id | pubmed-2147504 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1955 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21475042008-04-23 THE SPECIFIC HEAT AND THE HEAT OF COMPRESSION OF HUMAN RED CELLS, SICKLED RED CELLS, AND PARACRYSTALLINE RAT RED CELLS Ponder, Eric J Gen Physiol Article The investigation of two thermal properties of red cells throws some light on whether sickling is a process involving the crystallization of a relatively insoluble hemoglobin. These properties are the specific heat and the heat of compression, both of which would be expected to become numerically less if the hemoglobin of the red cell were to crystallize. In the case of paracrystalline rat red cells, which give spacings at 45 A and 58 A by x-ray diffraction, the specific heat is reduced to 85 per cent of that of the normal red cells, and the heat of compression is only about 75 per cent of that found for the normal red cell. In the case of the red cell sickled by a reduction of the O(2) tension, the specific heat and the heat of compression are substantially the same as found for the normal red cell. This is an argument against sickling being the result of a crystallization process, and supports the observation that sickled cells do not give x-ray spacings. The result is compatible, on the other hand, with sickling being the result of the formation of an oriented and birefringent gel. The Rockefeller University Press 1955-05-20 /pmc/articles/PMC2147504/ /pubmed/14367773 Text en Copyright © Copyright, 1955, by The Rockefeller Institute for Medical Research This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Ponder, Eric THE SPECIFIC HEAT AND THE HEAT OF COMPRESSION OF HUMAN RED CELLS, SICKLED RED CELLS, AND PARACRYSTALLINE RAT RED CELLS |
title | THE SPECIFIC HEAT AND THE HEAT OF COMPRESSION OF HUMAN RED CELLS, SICKLED RED CELLS, AND PARACRYSTALLINE RAT RED CELLS |
title_full | THE SPECIFIC HEAT AND THE HEAT OF COMPRESSION OF HUMAN RED CELLS, SICKLED RED CELLS, AND PARACRYSTALLINE RAT RED CELLS |
title_fullStr | THE SPECIFIC HEAT AND THE HEAT OF COMPRESSION OF HUMAN RED CELLS, SICKLED RED CELLS, AND PARACRYSTALLINE RAT RED CELLS |
title_full_unstemmed | THE SPECIFIC HEAT AND THE HEAT OF COMPRESSION OF HUMAN RED CELLS, SICKLED RED CELLS, AND PARACRYSTALLINE RAT RED CELLS |
title_short | THE SPECIFIC HEAT AND THE HEAT OF COMPRESSION OF HUMAN RED CELLS, SICKLED RED CELLS, AND PARACRYSTALLINE RAT RED CELLS |
title_sort | specific heat and the heat of compression of human red cells, sickled red cells, and paracrystalline rat red cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147504/ https://www.ncbi.nlm.nih.gov/pubmed/14367773 |
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