CHANGES IN MEMBRANE CHARACTERISTICS OF HEART MUSCLE DURING INHIBITION

Membrane characteristics were studied in isolated muscle strands from auricles of frogs using the "square pulse" technique. Changes in the time course and spatial spread of subthreshold electrotonic potentials were measured. If acetylcholine is applied in concentrations which cause slowing...

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Detalles Bibliográficos
Autores principales: Trautwein, W., Kuffler, S. W., Edwards, C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1956
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147603/
https://www.ncbi.nlm.nih.gov/pubmed/13357742
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author Trautwein, W.
Kuffler, S. W.
Edwards, C.
author_facet Trautwein, W.
Kuffler, S. W.
Edwards, C.
author_sort Trautwein, W.
collection PubMed
description Membrane characteristics were studied in isolated muscle strands from auricles of frogs using the "square pulse" technique. Changes in the time course and spatial spread of subthreshold electrotonic potentials were measured. If acetylcholine is applied in concentrations which cause slowing or stoppage of the heart beat, the following changes are produced: (a) the length constant (λ) of the membrane is reduced, (b) the time constant is shortened. The effects are reversible and increase with acetylcholine concentration. The membrane changes caused by acetylcholine dimmish with time. It is concluded that during acetylcholine inhibition, as well as during vagal inhibition, the conductance of the muscle membrane is increased. Appreciable changes in the resting membrane potential need not accompany inhibition.
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spelling pubmed-21476032008-04-23 CHANGES IN MEMBRANE CHARACTERISTICS OF HEART MUSCLE DURING INHIBITION Trautwein, W. Kuffler, S. W. Edwards, C. J Gen Physiol Article Membrane characteristics were studied in isolated muscle strands from auricles of frogs using the "square pulse" technique. Changes in the time course and spatial spread of subthreshold electrotonic potentials were measured. If acetylcholine is applied in concentrations which cause slowing or stoppage of the heart beat, the following changes are produced: (a) the length constant (λ) of the membrane is reduced, (b) the time constant is shortened. The effects are reversible and increase with acetylcholine concentration. The membrane changes caused by acetylcholine dimmish with time. It is concluded that during acetylcholine inhibition, as well as during vagal inhibition, the conductance of the muscle membrane is increased. Appreciable changes in the resting membrane potential need not accompany inhibition. The Rockefeller University Press 1956-09-20 /pmc/articles/PMC2147603/ /pubmed/13357742 Text en Copyright © Copyright, 1956, by The Rockefeller Institute for Medical Research This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Trautwein, W.
Kuffler, S. W.
Edwards, C.
CHANGES IN MEMBRANE CHARACTERISTICS OF HEART MUSCLE DURING INHIBITION
title CHANGES IN MEMBRANE CHARACTERISTICS OF HEART MUSCLE DURING INHIBITION
title_full CHANGES IN MEMBRANE CHARACTERISTICS OF HEART MUSCLE DURING INHIBITION
title_fullStr CHANGES IN MEMBRANE CHARACTERISTICS OF HEART MUSCLE DURING INHIBITION
title_full_unstemmed CHANGES IN MEMBRANE CHARACTERISTICS OF HEART MUSCLE DURING INHIBITION
title_short CHANGES IN MEMBRANE CHARACTERISTICS OF HEART MUSCLE DURING INHIBITION
title_sort changes in membrane characteristics of heart muscle during inhibition
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147603/
https://www.ncbi.nlm.nih.gov/pubmed/13357742
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AT kufflersw changesinmembranecharacteristicsofheartmuscleduringinhibition
AT edwardsc changesinmembranecharacteristicsofheartmuscleduringinhibition

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