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Serious adverse events following treatment with ivermectin for onchocerciasis control: a review of reported cases

This paper presents a summary of reported cases of Serious Adverse Events (SAEs) following treatment with Mectizan(® )(ivermectin, Merck, Sharpe & Dohme) in onchocerciasis mass treatment programs from January 1, 1989 to December 31, 2001 through a passive surveillance system. A total of 207 SAE...

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Autor principal: Twum-Danso, Nana AY
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147655/
https://www.ncbi.nlm.nih.gov/pubmed/14975060
http://dx.doi.org/10.1186/1475-2883-2-S1-S3
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author Twum-Danso, Nana AY
author_facet Twum-Danso, Nana AY
author_sort Twum-Danso, Nana AY
collection PubMed
description This paper presents a summary of reported cases of Serious Adverse Events (SAEs) following treatment with Mectizan(® )(ivermectin, Merck, Sharpe & Dohme) in onchocerciasis mass treatment programs from January 1, 1989 to December 31, 2001 through a passive surveillance system. A total of 207 SAE cases were reported out of approximately 165 million reported treatments delivered during the period under review, giving rise to a cumulative incidence of 1 reported SAE per 800,000 reported treatments. The mean age was 40 years and 70% of the cases were males. The mean time between ivermectin intake and onset of illness was 1 day. For 57% of the cases (n = 118), that was their first exposure to ivermectin. The majority of cases were reported from Cameroon (n = 176; 85%) with peaks in the incidence of SAE reporting in 1989–1991 and 1994–1995 when the program expanded to ivermectin-naïve populations. Fifty-five percent of the cases from Cameroon (i.e. 97 out of 176 cases) were encephalopathic and were reported from the central-southern region of the country; two-thirds of these cases were 'probable' or 'possible' cases of Loa loa encephalopathy temporally related to ivermectin treatment. Reporting bias may explain some but not all of the differences in SAE reporting between the 34 onchocerciasis-endemic countries that have, or have had, mass treatment programs. Further research is needed to understand the apparent clustering of encephalopathy cases in central-southern Cameroon since L. loa infection alone probably does not explain the increased incidence of this type of SAE from this region.
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spelling pubmed-21476552007-12-20 Serious adverse events following treatment with ivermectin for onchocerciasis control: a review of reported cases Twum-Danso, Nana AY Filaria J Review This paper presents a summary of reported cases of Serious Adverse Events (SAEs) following treatment with Mectizan(® )(ivermectin, Merck, Sharpe & Dohme) in onchocerciasis mass treatment programs from January 1, 1989 to December 31, 2001 through a passive surveillance system. A total of 207 SAE cases were reported out of approximately 165 million reported treatments delivered during the period under review, giving rise to a cumulative incidence of 1 reported SAE per 800,000 reported treatments. The mean age was 40 years and 70% of the cases were males. The mean time between ivermectin intake and onset of illness was 1 day. For 57% of the cases (n = 118), that was their first exposure to ivermectin. The majority of cases were reported from Cameroon (n = 176; 85%) with peaks in the incidence of SAE reporting in 1989–1991 and 1994–1995 when the program expanded to ivermectin-naïve populations. Fifty-five percent of the cases from Cameroon (i.e. 97 out of 176 cases) were encephalopathic and were reported from the central-southern region of the country; two-thirds of these cases were 'probable' or 'possible' cases of Loa loa encephalopathy temporally related to ivermectin treatment. Reporting bias may explain some but not all of the differences in SAE reporting between the 34 onchocerciasis-endemic countries that have, or have had, mass treatment programs. Further research is needed to understand the apparent clustering of encephalopathy cases in central-southern Cameroon since L. loa infection alone probably does not explain the increased incidence of this type of SAE from this region. BioMed Central 2003-10-24 /pmc/articles/PMC2147655/ /pubmed/14975060 http://dx.doi.org/10.1186/1475-2883-2-S1-S3 Text en
spellingShingle Review
Twum-Danso, Nana AY
Serious adverse events following treatment with ivermectin for onchocerciasis control: a review of reported cases
title Serious adverse events following treatment with ivermectin for onchocerciasis control: a review of reported cases
title_full Serious adverse events following treatment with ivermectin for onchocerciasis control: a review of reported cases
title_fullStr Serious adverse events following treatment with ivermectin for onchocerciasis control: a review of reported cases
title_full_unstemmed Serious adverse events following treatment with ivermectin for onchocerciasis control: a review of reported cases
title_short Serious adverse events following treatment with ivermectin for onchocerciasis control: a review of reported cases
title_sort serious adverse events following treatment with ivermectin for onchocerciasis control: a review of reported cases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147655/
https://www.ncbi.nlm.nih.gov/pubmed/14975060
http://dx.doi.org/10.1186/1475-2883-2-S1-S3
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