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Intermediate-affinity LFA-1 binds α-actinin-1 to control migration at the leading edge of the T cell
T lymphocytes use LFA-1 to migrate into lymph nodes and inflammatory sites. To investigate the mechanisms regulating this migration, we utilize mAbs selective for conformational epitopes as probes for active LFA-1. Expression of the KIM127 epitope, but not the 24 epitope, defines the extended confor...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147999/ https://www.ncbi.nlm.nih.gov/pubmed/18079697 http://dx.doi.org/10.1038/sj.emboj.7601959 |