Cargando…
Specific Myosin Heavy Chain Mutations Suppress Troponin I Defects in Drosophila Muscles
We show that specific mutations in the head of the thick filament molecule myosin heavy chain prevent a degenerative muscle syndrome resulting from the hdp(2) mutation in the thin filament protein troponin I. One mutation deletes eight residues from the actin binding loop of myosin, while a second a...
Autores principales: | Kronert, William A., Acebes, Angel, Ferrús, Alberto, Bernstein, Sanford I. |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1999
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2148188/ https://www.ncbi.nlm.nih.gov/pubmed/10085296 |
Ejemplares similares
-
Expression of the inclusion body myopathy 3 mutation in Drosophila depresses myosin function and stability and recapitulates muscle inclusions and weakness
por: Wang, Yang, et al.
Publicado: (2012) -
Reductions in ATPase activity, actin sliding velocity, and myofibril stability yield muscle dysfunction in Drosophila models of myosin-based Freeman–Sheldon syndrome
por: Rao, Deepti S., et al.
Publicado: (2019) -
Myosin heavy chain mutations that cause Freeman-Sheldon syndrome lead to muscle structural and functional defects in Drosophila
por: Das, Shreyasi, et al.
Publicado: (2019) -
Prolonged cross-bridge binding triggers muscle dysfunction in a Drosophila model of myosin-based hypertrophic cardiomyopathy
por: Kronert, William A, et al.
Publicado: (2018) -
Growth and Muscle Defects in Mice Lacking Adult Myosin Heavy Chain Genes
por: Acakpo-Satchivi, Leslie J.R., et al.
Publicado: (1997)