Cell Damage-induced Conformational Changes of the Pro-Apoptotic Protein Bak In Vivo Precede the Onset of Apoptosis

Investigation of events committing cells to death revealed that a concealed NH(2)-terminal epitope of the pro-apoptotic protein Bak became exposed in vivo before apoptosis. This occurred after treatment of human Jurkat or CEM-C7A T-lymphoma cells with the mechanistically disparate agents staurospori...

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Detalles Bibliográficos
Autores principales: Griffiths, Gareth J., Dubrez, Laurence, Morgan, Clive P., Jones, Neil A., Whitehouse, Jenna, Corfe, Bernard M., Dive, Caroline, Hickman, John A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Regular Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2148192/
https://www.ncbi.nlm.nih.gov/pubmed/10085290

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