Deubiquitination of FANCD2 Is Required for DNA Crosslink Repair

Monoubiquitination of FANCD2 and PCNA promotes DNA repair. It causes chromatin accumulation of FANCD2 and facilitates PCNA's recruitment of translesion polymerases to stalled replication. USP1, a protease that removes monoubiquitin from FANCD2 and PCNA, was thought to reverse the DNA damage res...

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Detalles Bibliográficos
Autores principales: Oestergaard, Vibe H., Langevin, Frederic, Kuiken, Hendrik J., Pace, Paul, Niedzwiedz, Wojciech, Simpson, Laura J., Ohzeki, Mioko, Takata, Minoru, Sale, Julian E., Patel, Ketan J.
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2148256/
https://www.ncbi.nlm.nih.gov/pubmed/18082605
http://dx.doi.org/10.1016/j.molcel.2007.09.020

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