Drosophila Centrosomin Protein is Required for Male Meiosis and Assembly of the Flagellar Axoneme

Centrosomes and microtubules play crucial roles during cell division and differentiation. Spermatogenesis is a useful system for studying centrosomal function since it involves both mitosis and meiosis, and also transformation of the centriole into the sperm basal body. Centrosomin is a protein loca...

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Autores principales: Li, Kaijun, Xu, Eugene Yujun, Cecil, Jeffrey K., Rudolf Turner, F., Megraw, Timothy L., Kaufman, Thomas C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2148447/
https://www.ncbi.nlm.nih.gov/pubmed/9548723
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author Li, Kaijun
Xu, Eugene Yujun
Cecil, Jeffrey K.
Rudolf Turner, F.
Megraw, Timothy L.
Kaufman, Thomas C.
author_facet Li, Kaijun
Xu, Eugene Yujun
Cecil, Jeffrey K.
Rudolf Turner, F.
Megraw, Timothy L.
Kaufman, Thomas C.
author_sort Li, Kaijun
collection PubMed
description Centrosomes and microtubules play crucial roles during cell division and differentiation. Spermatogenesis is a useful system for studying centrosomal function since it involves both mitosis and meiosis, and also transformation of the centriole into the sperm basal body. Centrosomin is a protein localized to the mitotic centrosomes in Drosophila melanogaster. We have found a novel isoform of centrosomin expressed during spermatogenesis. Additionally, an anticentrosomin antibody labels both the mitotic and meiotic centrosomes as well as the basal body. Mutational analysis shows that centrosomin is required for spindle organization during meiosis and for organization of the sperm axoneme. These results suggest that centrosomin is a necessary component of the meiotic centrosomes and the spermatid basal body.
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spelling pubmed-21484472008-05-01 Drosophila Centrosomin Protein is Required for Male Meiosis and Assembly of the Flagellar Axoneme Li, Kaijun Xu, Eugene Yujun Cecil, Jeffrey K. Rudolf Turner, F. Megraw, Timothy L. Kaufman, Thomas C. J Cell Biol Articles Centrosomes and microtubules play crucial roles during cell division and differentiation. Spermatogenesis is a useful system for studying centrosomal function since it involves both mitosis and meiosis, and also transformation of the centriole into the sperm basal body. Centrosomin is a protein localized to the mitotic centrosomes in Drosophila melanogaster. We have found a novel isoform of centrosomin expressed during spermatogenesis. Additionally, an anticentrosomin antibody labels both the mitotic and meiotic centrosomes as well as the basal body. Mutational analysis shows that centrosomin is required for spindle organization during meiosis and for organization of the sperm axoneme. These results suggest that centrosomin is a necessary component of the meiotic centrosomes and the spermatid basal body. The Rockefeller University Press 1998-04-20 /pmc/articles/PMC2148447/ /pubmed/9548723 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Li, Kaijun
Xu, Eugene Yujun
Cecil, Jeffrey K.
Rudolf Turner, F.
Megraw, Timothy L.
Kaufman, Thomas C.
Drosophila Centrosomin Protein is Required for Male Meiosis and Assembly of the Flagellar Axoneme
title Drosophila Centrosomin Protein is Required for Male Meiosis and Assembly of the Flagellar Axoneme
title_full Drosophila Centrosomin Protein is Required for Male Meiosis and Assembly of the Flagellar Axoneme
title_fullStr Drosophila Centrosomin Protein is Required for Male Meiosis and Assembly of the Flagellar Axoneme
title_full_unstemmed Drosophila Centrosomin Protein is Required for Male Meiosis and Assembly of the Flagellar Axoneme
title_short Drosophila Centrosomin Protein is Required for Male Meiosis and Assembly of the Flagellar Axoneme
title_sort drosophila centrosomin protein is required for male meiosis and assembly of the flagellar axoneme
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2148447/
https://www.ncbi.nlm.nih.gov/pubmed/9548723
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