Mutation of the p53 gene in human astrocytic tumours correlates with increased resistance to DNA-damaging agents but not to anti-microtubule anti-cancer agents.

Astrocytic tumours often become resistant to a variety of chemotherapeutic agents in advanced stages and frequently possess mutations in the p53 tumour-suppressor gene. Previous studies using established cell lines to investigate the relation between mutated p53 genes and altered resistance to anti-...

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Detalles Bibliográficos
Autores principales: Iwadate, Y., Tagawa, M., Fujimoto, S., Hirose, M., Namba, H., Sueyoshi, K., Sakiyama, S., Yamaura, A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2149936/
https://www.ncbi.nlm.nih.gov/pubmed/9484809

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