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Cytogenetic abnormalities in Langerhans cell histiocytosis.
We present the cytogenetic investigations of five histiocytic tumour lesions from children. In four cases there was a confirmed diagnosis of Langerhans cell histiocytosis (LCH) and one case of histiocytosis that did not fulfil all the criteria for true LCH. All five cases showed cytogenetic abnormal...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
1998
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2149945/ https://www.ncbi.nlm.nih.gov/pubmed/9484810 |
| _version_ | 1782144555908333568 |
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| author | Betts, D. R. Leibundgut, K. E. Feldges, A. Plüss, H. J. Niggli, F. K. |
| author_facet | Betts, D. R. Leibundgut, K. E. Feldges, A. Plüss, H. J. Niggli, F. K. |
| author_sort | Betts, D. R. |
| collection | PubMed |
| description | We present the cytogenetic investigations of five histiocytic tumour lesions from children. In four cases there was a confirmed diagnosis of Langerhans cell histiocytosis (LCH) and one case of histiocytosis that did not fulfil all the criteria for true LCH. All five cases showed cytogenetic abnormalities, including the first report of an abnormal clone in LCH. The clone showed a t(7;12)(q11.2;p13) translocation and was detected in only a small percentage of cells. This case and a further three also contained non-clonal abnormalities and an increase in chromosome breakage. The fifth case, the only one in which no acquired abnormalities were seen, had a constitutional paracentric inversion of chromosome 13q. IMAGES: |
| format | Text |
| id | pubmed-2149945 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 1998 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-21499452009-09-10 Cytogenetic abnormalities in Langerhans cell histiocytosis. Betts, D. R. Leibundgut, K. E. Feldges, A. Plüss, H. J. Niggli, F. K. Br J Cancer Research Article We present the cytogenetic investigations of five histiocytic tumour lesions from children. In four cases there was a confirmed diagnosis of Langerhans cell histiocytosis (LCH) and one case of histiocytosis that did not fulfil all the criteria for true LCH. All five cases showed cytogenetic abnormalities, including the first report of an abnormal clone in LCH. The clone showed a t(7;12)(q11.2;p13) translocation and was detected in only a small percentage of cells. This case and a further three also contained non-clonal abnormalities and an increase in chromosome breakage. The fifth case, the only one in which no acquired abnormalities were seen, had a constitutional paracentric inversion of chromosome 13q. IMAGES: Nature Publishing Group 1998-02 /pmc/articles/PMC2149945/ /pubmed/9484810 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Research Article Betts, D. R. Leibundgut, K. E. Feldges, A. Plüss, H. J. Niggli, F. K. Cytogenetic abnormalities in Langerhans cell histiocytosis. |
| title | Cytogenetic abnormalities in Langerhans cell histiocytosis. |
| title_full | Cytogenetic abnormalities in Langerhans cell histiocytosis. |
| title_fullStr | Cytogenetic abnormalities in Langerhans cell histiocytosis. |
| title_full_unstemmed | Cytogenetic abnormalities in Langerhans cell histiocytosis. |
| title_short | Cytogenetic abnormalities in Langerhans cell histiocytosis. |
| title_sort | cytogenetic abnormalities in langerhans cell histiocytosis. |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2149945/ https://www.ncbi.nlm.nih.gov/pubmed/9484810 |
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