The effects of n-6 polyunsaturated fatty acids on the expression of nm-23 in human cancer cells.

This study examined the effect of n-6 polyunsaturated fatty acids (PUFAs) on the expression of nm-23, a metastasis-suppressor gene, in two highly invasive human cancer cell lines, HT115 and MDA MB 231. A range of n-6 and n-3 PUFAs were tested. We report that while linoleic acid and arachidonic acid...

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Autores principales: Jiang, W. G., Hiscox, S., Bryce, R. P., Horrobin, D. F., Mansel, R. E.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2149954/
https://www.ncbi.nlm.nih.gov/pubmed/9514051
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author Jiang, W. G.
Hiscox, S.
Bryce, R. P.
Horrobin, D. F.
Mansel, R. E.
author_facet Jiang, W. G.
Hiscox, S.
Bryce, R. P.
Horrobin, D. F.
Mansel, R. E.
author_sort Jiang, W. G.
collection PubMed
description This study examined the effect of n-6 polyunsaturated fatty acids (PUFAs) on the expression of nm-23, a metastasis-suppressor gene, in two highly invasive human cancer cell lines, HT115 and MDA MB 231. A range of n-6 and n-3 PUFAs were tested. We report that while linoleic acid and arachidonic acid reduced the expression of nm-23-H1, gamma linolenic acid (GLA) and its soluble lithium salt markedly increased the expression of the molecules. The stimulation of the expression of nm-23 by GLA was seen at both protein and mRNA levels. Up-regulation of nm-23 was also associated with a reduction of the in vitro invasiveness of these cells. It is concluded that gamma linolenic acid (GLA) enhances the expression of nm-23. This contributes to the inhibition of the in vitro invasion of tumour cells. IMAGES:
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spelling pubmed-21499542009-09-10 The effects of n-6 polyunsaturated fatty acids on the expression of nm-23 in human cancer cells. Jiang, W. G. Hiscox, S. Bryce, R. P. Horrobin, D. F. Mansel, R. E. Br J Cancer Research Article This study examined the effect of n-6 polyunsaturated fatty acids (PUFAs) on the expression of nm-23, a metastasis-suppressor gene, in two highly invasive human cancer cell lines, HT115 and MDA MB 231. A range of n-6 and n-3 PUFAs were tested. We report that while linoleic acid and arachidonic acid reduced the expression of nm-23-H1, gamma linolenic acid (GLA) and its soluble lithium salt markedly increased the expression of the molecules. The stimulation of the expression of nm-23 by GLA was seen at both protein and mRNA levels. Up-regulation of nm-23 was also associated with a reduction of the in vitro invasiveness of these cells. It is concluded that gamma linolenic acid (GLA) enhances the expression of nm-23. This contributes to the inhibition of the in vitro invasion of tumour cells. IMAGES: Nature Publishing Group 1998-03 /pmc/articles/PMC2149954/ /pubmed/9514051 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Jiang, W. G.
Hiscox, S.
Bryce, R. P.
Horrobin, D. F.
Mansel, R. E.
The effects of n-6 polyunsaturated fatty acids on the expression of nm-23 in human cancer cells.
title The effects of n-6 polyunsaturated fatty acids on the expression of nm-23 in human cancer cells.
title_full The effects of n-6 polyunsaturated fatty acids on the expression of nm-23 in human cancer cells.
title_fullStr The effects of n-6 polyunsaturated fatty acids on the expression of nm-23 in human cancer cells.
title_full_unstemmed The effects of n-6 polyunsaturated fatty acids on the expression of nm-23 in human cancer cells.
title_short The effects of n-6 polyunsaturated fatty acids on the expression of nm-23 in human cancer cells.
title_sort effects of n-6 polyunsaturated fatty acids on the expression of nm-23 in human cancer cells.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2149954/
https://www.ncbi.nlm.nih.gov/pubmed/9514051
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