Oestrogen-regulated genes in breast cancer: association of pLIV1 with response to endocrine therapy.

Northern hybridization analyses of the oestrogen-inducible mRNAs pLIV1 and pS2 were compared with oestrogen receptor (ER) immunocytochemistry assessments in 40 untreated primary or early recurrent breast tumours. Significant associations were observed between pLIV1/ER (P < 0.03), pS2/ER (P < 0...

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Autores principales: McClelland, R. A., Manning, D. L., Gee, J. M., Willsher, P., Robertson, J. F., Ellis, I. O., Blamey, R. W., Nicholson, R. I.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150074/
https://www.ncbi.nlm.nih.gov/pubmed/9635843
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author McClelland, R. A.
Manning, D. L.
Gee, J. M.
Willsher, P.
Robertson, J. F.
Ellis, I. O.
Blamey, R. W.
Nicholson, R. I.
author_facet McClelland, R. A.
Manning, D. L.
Gee, J. M.
Willsher, P.
Robertson, J. F.
Ellis, I. O.
Blamey, R. W.
Nicholson, R. I.
author_sort McClelland, R. A.
collection PubMed
description Northern hybridization analyses of the oestrogen-inducible mRNAs pLIV1 and pS2 were compared with oestrogen receptor (ER) immunocytochemistry assessments in 40 untreated primary or early recurrent breast tumours. Significant associations were observed between pLIV1/ER (P < 0.03), pS2/ER (P < 0.001) and pLIV1/pS2 (P < 0.04) status. After disease recurrence, patients were treated with assessable courses of endocrine therapies. Positive pLIV1, pS2 and ER statuses in primary disease were consequently found to be predictive of endocrine responsiveness in the secondary lesions (P < 0.03, P < 0.02, P < 0.005 respectively). However, despite these associations, a number of pLIV1- and/or pS2-positive tumours failed to respond to therapy.
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spelling pubmed-21500742009-09-10 Oestrogen-regulated genes in breast cancer: association of pLIV1 with response to endocrine therapy. McClelland, R. A. Manning, D. L. Gee, J. M. Willsher, P. Robertson, J. F. Ellis, I. O. Blamey, R. W. Nicholson, R. I. Br J Cancer Research Article Northern hybridization analyses of the oestrogen-inducible mRNAs pLIV1 and pS2 were compared with oestrogen receptor (ER) immunocytochemistry assessments in 40 untreated primary or early recurrent breast tumours. Significant associations were observed between pLIV1/ER (P < 0.03), pS2/ER (P < 0.001) and pLIV1/pS2 (P < 0.04) status. After disease recurrence, patients were treated with assessable courses of endocrine therapies. Positive pLIV1, pS2 and ER statuses in primary disease were consequently found to be predictive of endocrine responsiveness in the secondary lesions (P < 0.03, P < 0.02, P < 0.005 respectively). However, despite these associations, a number of pLIV1- and/or pS2-positive tumours failed to respond to therapy. Nature Publishing Group 1998-05 /pmc/articles/PMC2150074/ /pubmed/9635843 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
McClelland, R. A.
Manning, D. L.
Gee, J. M.
Willsher, P.
Robertson, J. F.
Ellis, I. O.
Blamey, R. W.
Nicholson, R. I.
Oestrogen-regulated genes in breast cancer: association of pLIV1 with response to endocrine therapy.
title Oestrogen-regulated genes in breast cancer: association of pLIV1 with response to endocrine therapy.
title_full Oestrogen-regulated genes in breast cancer: association of pLIV1 with response to endocrine therapy.
title_fullStr Oestrogen-regulated genes in breast cancer: association of pLIV1 with response to endocrine therapy.
title_full_unstemmed Oestrogen-regulated genes in breast cancer: association of pLIV1 with response to endocrine therapy.
title_short Oestrogen-regulated genes in breast cancer: association of pLIV1 with response to endocrine therapy.
title_sort oestrogen-regulated genes in breast cancer: association of pliv1 with response to endocrine therapy.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150074/
https://www.ncbi.nlm.nih.gov/pubmed/9635843
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