Neuromuscular toxicities of paclitaxel 210 mg m(-2) by 3-hour infusion.

We retrospectively analysed neuromuscular toxicity associated with paclitaxel 210 mg m(-2) given by 3-h infusion in 247 patients. The severity correlated significantly with total cumulative dose, but could not be predicted by the pretreatment clinical variables or by pharmacokinetic parameters. The...

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Detalles Bibliográficos
Autores principales: Kunitoh, H., Saijo, N., Furuse, K., Noda, K., Ogawa, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150075/
https://www.ncbi.nlm.nih.gov/pubmed/9635850
Descripción
Sumario:We retrospectively analysed neuromuscular toxicity associated with paclitaxel 210 mg m(-2) given by 3-h infusion in 247 patients. The severity correlated significantly with total cumulative dose, but could not be predicted by the pretreatment clinical variables or by pharmacokinetic parameters. The toxicity tended to occur in early treatment cycles.

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