Cargando…

The retinoblastoma protein-associated cell cycle arrest in S-phase under moderate hypoxia is disrupted in cells expressing HPV18 E7 oncoprotein.

We have studied the role of the oxygen-dependent pyrimidine metabolism in the regulation of cell cycle progression under moderate hypoxia in human cell lines containing functional (T-47D) or non-functional (NHIK 3025, SAOS-2) retinoblastoma gene product (pRB). Under aerobic conditions, pRB exerts it...

Descripción completa

Detalles Bibliográficos
Autores principales:	Amellem, O., Sandvik, J. A., Stokke, T., Pettersen, E. O.
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1998
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150090/ https://www.ncbi.nlm.nih.gov/pubmed/9528826

Ejemplares similares

Regulation of cell proliferation under extreme and moderate hypoxia: the role of pyrimidine (deoxy)nucleotides.
por: Amellem, O., et al.
Publicado: (1994)

Hypoxia induces p53 accumulation in the S-phase and accumulation of hypophosphorylated retinoblastoma protein in all cell cycle phases of human melanoma cells.
por: Danielsen, T., et al.
Publicado: (1998)

Retinoblastoma-independent antiproliferative activity of novel intracellular antibodies against the E7 oncoprotein in HPV 16-positive cells
por: Accardi, Luisa, et al.
Publicado: (2011)

Expression of the HPV18/E6 oncoprotein induces DNA damage
por: Gutierrez, Elva I. Cortes, et al.
Publicado: (2017)

Manipulation of Epithelial Differentiation by HPV Oncoproteins
por: White, Elizabeth A.
Publicado: (2019)

Inhibition of cell-cycle progression by acute treatment with various degrees of hypoxia: modifications induced by low concentrations of misonidazole present during hypoxia.
por: Pettersen, E. O., et al.
Publicado: (1983)

2-Methyl 2-butanol suppresses human retinoblastoma cells through cell cycle arrest and autophagy
por: Li, Xiangyun, et al.
Publicado: (2018)

Cell Cycle Regulatory Functions of the KSHV Oncoprotein LANA
por: Wei, Fang, et al.
Publicado: (2016)

Expression of the HPV16E7 Oncoprotein by Thymic Epithelium is Accompanied by Disrupted T Cell Maturation and a Failure of the Thymus to Involute with Age
por: Malcolm, K. M., et al.
Publicado: (2003)

Downregulation of NIMA-related kinase-7 inhibits cell proliferation by inducing cell cycle arrest in human retinoblastoma cells
por: Zhang, Jian, et al.
Publicado: (2018)

A comprehensive in silico analysis for identification of therapeutic epitopes in HPV16, 18, 31 and 45 oncoproteins
por: Panahi, Heidar Ali, et al.
Publicado: (2018)

Hypoxia inducible factor-1 alpha expression is increased in infected positive HPV16 DNA oral squamous cell carcinoma and positively associated with HPV16 E7 oncoprotein
por: Rodolico, Vito, et al.
Publicado: (2011)

HPV18 E1^E4 is assembled into aggresome-like compartment and involved in sequestration of viral oncoproteins.
por: Kajitani, Naoko, et al.
Publicado: (2013)

Rb induces a proliferative arrest and curtails Brn-2 expression in retinoblastoma cells
por: Cobrinik, David, et al.
Publicado: (2006)

HPV Oncoproteins and the Ubiquitin Proteasome System: A Signature of Malignancy?
por: Đukić, Anamaria, et al.
Publicado: (2020)

HPV infections in retinoblastoma: a systematic review
por: Soltani, Saber, et al.
Publicado: (2021)

The Aqueous Extract of Ficus religiosa Induces Cell Cycle Arrest in Human Cervical Cancer Cell Lines SiHa (HPV-16 Positive) and Apoptosis in HeLa (HPV-18 Positive)
por: Choudhari, Amit S., et al.
Publicado: (2013)

Inhibition of kinase IKKβ suppresses cellular abnormalities induced by the human papillomavirus oncoprotein HPV 18E6
por: Padash Barmchi, Mojgan, et al.
Publicado: (2021)

Hypoxia Strongly Affects Mitochondrial Ribosomal Proteins and Translocases, as Shown by Quantitative Proteomics of HeLa Cells
por: Bousquet, Paula A., et al.
Publicado: (2015)

Roles of plant retinoblastoma protein: cell cycle and beyond
por: Desvoyes, Bénédicte, et al.
Publicado: (2020)

Low concentrations of misonidazole counteract effects of extreme hypoxia on cells in S.
por: Pettersen, E. O., et al.
Publicado: (1981)

hrHPV E5 oncoprotein: immune evasion and related immunotherapies
por: de Freitas, Antonio Carlos, et al.
Publicado: (2017)

The HPV16 E7 Oncoprotein Disrupts Dendritic Cell Function and Induces the Systemic Expansion of CD11b(+)Gr1(+) Cells in a Transgenic Mouse Model
por: Damian-Morales, Gabriela, et al.
Publicado: (2016)

DNA ploidy in primary testicular cancer.
por: Fosså, S. D., et al.
Publicado: (1991)

miR-133a-3p promotes apoptosis and induces cell cycle arrest by targeting CREB1 in retinoblastoma
por: Li, Jianchang, et al.
Publicado: (2019)

DNA virus oncoprotein HPV18 E7 selectively antagonizes cGAS‐STING‐triggered innate immune activation
por: Lou, Meng, et al.
Publicado: (2022)

Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest
por: Raz, S, et al.
Publicado: (2014)

Mitochondrial Function of CKS2 Oncoprotein Links Oxidative Phosphorylation with Cell Division in Chemoradioresistant Cervical Cancer()
por: Jonsson, Marte, et al.
Publicado: (2019)

Development and validation of a multiplex immunoassay for the simultaneous quantification of type-specific IgG antibodies to E6/E7 oncoproteins of HPV16 and HPV18
por: Layman, Hans, et al.
Publicado: (2020)

Transcriptional regulation of E-cadherin and oncoprotein E7 by valproic acid in HPV positive cell lines
por: Faghihloo, Ebrahim, et al.
Publicado: (2016)

Serum HPV16 E7 Oncoprotein Is a Recurrence Marker of Oropharyngeal Squamous Cell Carcinomas
por: Oton-Gonzalez, Lucia, et al.
Publicado: (2021)

Newt Myotubes Reenter the Cell Cycle by Phosphorylation of the Retinoblastoma Protein
por: Tanaka, Elly M., et al.
Publicado: (1997)

Identification of cytotoxic agents disrupting synovial sarcoma oncoprotein interactions by proximity ligation assay
por: Laporte, Aimée N., et al.
Publicado: (2016)

Inactivation of nucleolin leads to nucleolar disruption, cell cycle arrest and defects in centrosome duplication
por: Ugrinova, Iva, et al.
Publicado: (2007)

DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1
Publicado: (1994)

Bufadienolides from Venenum Bufonis Inhibit mTOR-Mediated Cyclin D1 and Retinoblastoma Protein Leading to Arrest of Cell Cycle in Cancer Cells
por: Chang, Huamei, et al.
Publicado: (2018)

Resveratrol and Pterostilbene Exhibit Anticancer Properties Involving the Downregulation of HPV Oncoprotein E6 in Cervical Cancer Cells
por: Chatterjee, Kaushiki, et al.
Publicado: (2018)

Novel Affibody Molecules Targeting the HPV16 E6 Oncoprotein Inhibited the Proliferation of Cervical Cancer Cells
por: Zhu, Jinshun, et al.
Publicado: (2021)

9-oxo-ODAs suppresses the proliferation of human cervical cancer cells through the inhibition of CDKs and HPV oncoproteins
por: Mogi, Kazumasa, et al.
Publicado: (2023)

Platelet-activating factor induces cell cycle arrest and disrupts the DNA damage response in mast cells
por: Puebla-Osorio, N, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_bvc02elacl26kh81m8p4i06u2n