Raltitrexed (Tomudex): an alternative drug for patients with colorectal cancer and 5-fluorouracil associated cardiotoxicity.

Two patients with proven 5-fluorouracil (5-FU)-associated cardiotoxicity were treated with the specific thymidylate synthase inhibitor raltitrexed safely, without evidence of cardiotoxicity. Raltitrexed might be an alternative for patients with advanced colorectal cancer and 5-FU-associated cardioto...

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Autores principales: Köhne, C. H., Thuss-Patience, P., Friedrich, M., Daniel, P. T., Kretzschmar, A., Benter, T., Bauer, B., Dietz, R., Dörken, B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150099/
https://www.ncbi.nlm.nih.gov/pubmed/9528843
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author Köhne, C. H.
Thuss-Patience, P.
Friedrich, M.
Daniel, P. T.
Kretzschmar, A.
Benter, T.
Bauer, B.
Dietz, R.
Dörken, B.
author_facet Köhne, C. H.
Thuss-Patience, P.
Friedrich, M.
Daniel, P. T.
Kretzschmar, A.
Benter, T.
Bauer, B.
Dietz, R.
Dörken, B.
author_sort Köhne, C. H.
collection PubMed
description Two patients with proven 5-fluorouracil (5-FU)-associated cardiotoxicity were treated with the specific thymidylate synthase inhibitor raltitrexed safely, without evidence of cardiotoxicity. Raltitrexed might be an alternative for patients with advanced colorectal cancer and 5-FU-associated cardiotoxicity. 5-FU cardiotoxicity is not due to the antineoplastic mechanisms via thymidilate synthase. IMAGES:
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spelling pubmed-21500992009-09-10 Raltitrexed (Tomudex): an alternative drug for patients with colorectal cancer and 5-fluorouracil associated cardiotoxicity. Köhne, C. H. Thuss-Patience, P. Friedrich, M. Daniel, P. T. Kretzschmar, A. Benter, T. Bauer, B. Dietz, R. Dörken, B. Br J Cancer Research Article Two patients with proven 5-fluorouracil (5-FU)-associated cardiotoxicity were treated with the specific thymidylate synthase inhibitor raltitrexed safely, without evidence of cardiotoxicity. Raltitrexed might be an alternative for patients with advanced colorectal cancer and 5-FU-associated cardiotoxicity. 5-FU cardiotoxicity is not due to the antineoplastic mechanisms via thymidilate synthase. IMAGES: Nature Publishing Group 1998-03 /pmc/articles/PMC2150099/ /pubmed/9528843 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Köhne, C. H.
Thuss-Patience, P.
Friedrich, M.
Daniel, P. T.
Kretzschmar, A.
Benter, T.
Bauer, B.
Dietz, R.
Dörken, B.
Raltitrexed (Tomudex): an alternative drug for patients with colorectal cancer and 5-fluorouracil associated cardiotoxicity.
title Raltitrexed (Tomudex): an alternative drug for patients with colorectal cancer and 5-fluorouracil associated cardiotoxicity.
title_full Raltitrexed (Tomudex): an alternative drug for patients with colorectal cancer and 5-fluorouracil associated cardiotoxicity.
title_fullStr Raltitrexed (Tomudex): an alternative drug for patients with colorectal cancer and 5-fluorouracil associated cardiotoxicity.
title_full_unstemmed Raltitrexed (Tomudex): an alternative drug for patients with colorectal cancer and 5-fluorouracil associated cardiotoxicity.
title_short Raltitrexed (Tomudex): an alternative drug for patients with colorectal cancer and 5-fluorouracil associated cardiotoxicity.
title_sort raltitrexed (tomudex): an alternative drug for patients with colorectal cancer and 5-fluorouracil associated cardiotoxicity.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150099/
https://www.ncbi.nlm.nih.gov/pubmed/9528843
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