Mutations in residues of TP53 that directly contact DNA predict poor outcome in human primary breast cancer.

The tumour-suppressor gene TP53 is frequently mutated in breast tumours, and the majority of the mutations are clustered within the core domain, the region involved in DNA binding. We searched for alterations in this central domain of the TP53gene in 222 human breast cancer specimens using polymeras...

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Detalles Bibliográficos
Autores principales: Berns, E. M., van Staveren, I. L., Look, M. P., Smid, M., Klijn, J. G., Foekens, J. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150115/
https://www.ncbi.nlm.nih.gov/pubmed/9569050

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