A missense mutation in the BRCA2 gene in three siblings with ovarian cancer.

Inherited susceptibility to ovarian cancer has been associated with germline defects at several loci. The major known ovarian cancer susceptibility gene is BRCA1 on chromosome 17q, which confers a risk of approximately 60% by the age of 70 years. Truncating mutations in BRCA2 on chromosome 13q also...

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Detalles Bibliográficos
Autores principales: Roth, S., Kristo, P., Auranen, A., Shayehgi, M., Seal, S., Collins, N., Barfoot, R., Rahman, N., Klemi, P. J., Grénman, S., Sarantaus, L., Nevanlinna, H., Butzow, R., Ashworth, A., Stratton, M. R., Aaltonen, L. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150153/
https://www.ncbi.nlm.nih.gov/pubmed/9579822

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