Modulation of P450-dependent ifosfamide pharmacokinetics: a better understanding of drug activation in vivo.

The anti-cancer prodrug ifosfamide (IF) is metabolized by liver P450 enzymes by two alternative pathways. IF is activated to 4-hydroxy IF (4-OH-IF), which ultimately yields the alkylating mustard isophosphoramide, whereas IF N-dechlororethylation inactivates the drug and produces the neurotoxic meta...

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Detalles Bibliográficos
Autores principales: Brain, E. G., Yu, L. J., Gustafsson, K., Drewes, P., Waxman, D. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150313/
https://www.ncbi.nlm.nih.gov/pubmed/9667645

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150313/
https://www.ncbi.nlm.nih.gov/pubmed/9667645

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