Cargando…
A study of the feasibility and accuracy of pharmacokinetically guided etoposide dosing in children.
Pharmacokinetically guided dosing was performed in nine paediatric patients receiving etoposide. Doses on day 2 of a 2- or 3-day schedule were adapted on the basis of the day-1 area under the plasma etoposide concentration vs time curve (AUC). The day-1 AUC was estimated using a limited sampling mod...
Autores principales: | , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
1998
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150379/ https://www.ncbi.nlm.nih.gov/pubmed/9649152 |
_version_ | 1782144611947380736 |
---|---|
author | Lowis, S. P. Price, L. Pearson, A. D. Newell, D. R. Cole, M. |
author_facet | Lowis, S. P. Price, L. Pearson, A. D. Newell, D. R. Cole, M. |
author_sort | Lowis, S. P. |
collection | PubMed |
description | Pharmacokinetically guided dosing was performed in nine paediatric patients receiving etoposide. Doses on day 2 of a 2- or 3-day schedule were adapted on the basis of the day-1 area under the plasma etoposide concentration vs time curve (AUC). The day-1 AUC was estimated using a limited sampling model and the day-2 target AUC defined by the etoposide dose-AUC relationship observed in 33 children. Target AUC values (4.6-8.2 mg ml(-1) x min) were achieved with a high degree of precision and with little bias (mean error 11% and root mean squared error 15% respectively). Pharmacokinetic parameters were similar to those reported previously in children, although interpatient pharmacokinetic variability was less than that observed previously: plasma clearance, 23 (18-26) ml min(-1) m(-2); volume of distribution at steady state (Vdss), 6.0 (3.9-8.9) l m(-2); t(1/2) 254 (127-550) min (median and range). This study has demonstrated that pharmacokinetically guided dosing with etoposide is feasible. However, pharmacokinetically guided dosing is likely to be of most benefit in patients with abnormalities of renal or hepatic function, or in children with prior exposure to cisplatin. |
format | Text |
id | pubmed-2150379 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1998 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-21503792009-09-10 A study of the feasibility and accuracy of pharmacokinetically guided etoposide dosing in children. Lowis, S. P. Price, L. Pearson, A. D. Newell, D. R. Cole, M. Br J Cancer Research Article Pharmacokinetically guided dosing was performed in nine paediatric patients receiving etoposide. Doses on day 2 of a 2- or 3-day schedule were adapted on the basis of the day-1 area under the plasma etoposide concentration vs time curve (AUC). The day-1 AUC was estimated using a limited sampling model and the day-2 target AUC defined by the etoposide dose-AUC relationship observed in 33 children. Target AUC values (4.6-8.2 mg ml(-1) x min) were achieved with a high degree of precision and with little bias (mean error 11% and root mean squared error 15% respectively). Pharmacokinetic parameters were similar to those reported previously in children, although interpatient pharmacokinetic variability was less than that observed previously: plasma clearance, 23 (18-26) ml min(-1) m(-2); volume of distribution at steady state (Vdss), 6.0 (3.9-8.9) l m(-2); t(1/2) 254 (127-550) min (median and range). This study has demonstrated that pharmacokinetically guided dosing with etoposide is feasible. However, pharmacokinetically guided dosing is likely to be of most benefit in patients with abnormalities of renal or hepatic function, or in children with prior exposure to cisplatin. Nature Publishing Group 1998-06 /pmc/articles/PMC2150379/ /pubmed/9649152 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Lowis, S. P. Price, L. Pearson, A. D. Newell, D. R. Cole, M. A study of the feasibility and accuracy of pharmacokinetically guided etoposide dosing in children. |
title | A study of the feasibility and accuracy of pharmacokinetically guided etoposide dosing in children. |
title_full | A study of the feasibility and accuracy of pharmacokinetically guided etoposide dosing in children. |
title_fullStr | A study of the feasibility and accuracy of pharmacokinetically guided etoposide dosing in children. |
title_full_unstemmed | A study of the feasibility and accuracy of pharmacokinetically guided etoposide dosing in children. |
title_short | A study of the feasibility and accuracy of pharmacokinetically guided etoposide dosing in children. |
title_sort | study of the feasibility and accuracy of pharmacokinetically guided etoposide dosing in children. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150379/ https://www.ncbi.nlm.nih.gov/pubmed/9649152 |
work_keys_str_mv | AT lowissp astudyofthefeasibilityandaccuracyofpharmacokineticallyguidedetoposidedosinginchildren AT pricel astudyofthefeasibilityandaccuracyofpharmacokineticallyguidedetoposidedosinginchildren AT pearsonad astudyofthefeasibilityandaccuracyofpharmacokineticallyguidedetoposidedosinginchildren AT newelldr astudyofthefeasibilityandaccuracyofpharmacokineticallyguidedetoposidedosinginchildren AT colem astudyofthefeasibilityandaccuracyofpharmacokineticallyguidedetoposidedosinginchildren AT lowissp studyofthefeasibilityandaccuracyofpharmacokineticallyguidedetoposidedosinginchildren AT pricel studyofthefeasibilityandaccuracyofpharmacokineticallyguidedetoposidedosinginchildren AT pearsonad studyofthefeasibilityandaccuracyofpharmacokineticallyguidedetoposidedosinginchildren AT newelldr studyofthefeasibilityandaccuracyofpharmacokineticallyguidedetoposidedosinginchildren AT colem studyofthefeasibilityandaccuracyofpharmacokineticallyguidedetoposidedosinginchildren |