Determinants of CPT-11 and SN-38 activities in human lung cancer cells.

Irinotecan (CPT-11) is a semisynthetic camptothecin derivative with a broad spectrum of anti-tumour activity. Carboxylesterase (CE) catalyses the conversion of CPT-11 to SN-38 (7-ethyl-10-hydroxycamptothecin), the active form of CPT-11. The antiproliferative effects of CPT-11 and SN-38, CE-activity...

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Detalles Bibliográficos
Autores principales: van Ark-Otte, J., Kedde, M. A., van der Vijgh, W. J., Dingemans, A. M., Jansen, W. J., Pinedo, H. M., Boven, E., Giaccone, G.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150393/
https://www.ncbi.nlm.nih.gov/pubmed/9649129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150393/
https://www.ncbi.nlm.nih.gov/pubmed/9649129

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