Telomerase activity in benign and malignant human thyroid tissues.

Telomerase is a specialized ribonucleoprotein polymerase that directs the synthesis of telomerase repeats at chromosome ends. Accumulating evidence has indicated that telomerase is stringently repressed in normal human somatic tissues but reactivated in cancers and immortal cells, suggesting that ac...

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Autores principales: Cheng, A. J., Lin, J. D., Chang, T., Wang, T. C.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150404/
https://www.ncbi.nlm.nih.gov/pubmed/9649130
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author Cheng, A. J.
Lin, J. D.
Chang, T.
Wang, T. C.
author_facet Cheng, A. J.
Lin, J. D.
Chang, T.
Wang, T. C.
author_sort Cheng, A. J.
collection PubMed
description Telomerase is a specialized ribonucleoprotein polymerase that directs the synthesis of telomerase repeats at chromosome ends. Accumulating evidence has indicated that telomerase is stringently repressed in normal human somatic tissues but reactivated in cancers and immortal cells, suggesting that activation of telomerase activity plays a role in carcinogenesis and immortalization. In this work, the status of telomerase activity during the development of human thyroid cancer was determined using telomeric repeat amplification protocol (TRAP) in 14 nodular hyperplasia, 14 adenomas, 23 papillary carcinomas and 11 follicular carcinomas. Positive telomerase activity was detected in 2 of 14 nodular hyperplasias (14%), 4 of 14 adenomas (29%), 12 of 23 papillary carcinomas (52%) and 10 of 11 follicular carcinomas (91%). The cancers that are negative for telomerase activity are mostly in early stage (stage I or II). These results suggest that telomerase reactivation plays a role during the development of thyroid cancer. IMAGES:
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spelling pubmed-21504042009-09-10 Telomerase activity in benign and malignant human thyroid tissues. Cheng, A. J. Lin, J. D. Chang, T. Wang, T. C. Br J Cancer Research Article Telomerase is a specialized ribonucleoprotein polymerase that directs the synthesis of telomerase repeats at chromosome ends. Accumulating evidence has indicated that telomerase is stringently repressed in normal human somatic tissues but reactivated in cancers and immortal cells, suggesting that activation of telomerase activity plays a role in carcinogenesis and immortalization. In this work, the status of telomerase activity during the development of human thyroid cancer was determined using telomeric repeat amplification protocol (TRAP) in 14 nodular hyperplasia, 14 adenomas, 23 papillary carcinomas and 11 follicular carcinomas. Positive telomerase activity was detected in 2 of 14 nodular hyperplasias (14%), 4 of 14 adenomas (29%), 12 of 23 papillary carcinomas (52%) and 10 of 11 follicular carcinomas (91%). The cancers that are negative for telomerase activity are mostly in early stage (stage I or II). These results suggest that telomerase reactivation plays a role during the development of thyroid cancer. IMAGES: Nature Publishing Group 1998-06 /pmc/articles/PMC2150404/ /pubmed/9649130 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Cheng, A. J.
Lin, J. D.
Chang, T.
Wang, T. C.
Telomerase activity in benign and malignant human thyroid tissues.
title Telomerase activity in benign and malignant human thyroid tissues.
title_full Telomerase activity in benign and malignant human thyroid tissues.
title_fullStr Telomerase activity in benign and malignant human thyroid tissues.
title_full_unstemmed Telomerase activity in benign and malignant human thyroid tissues.
title_short Telomerase activity in benign and malignant human thyroid tissues.
title_sort telomerase activity in benign and malignant human thyroid tissues.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150404/
https://www.ncbi.nlm.nih.gov/pubmed/9649130
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AT wangtc telomeraseactivityinbenignandmalignanthumanthyroidtissues

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