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The Reduction of Chromosome Number in Meiosis Is Determined by Properties Built into the Chromosomes

In meiosis I, two chromatids move to each spindle pole. Then, in meiosis II, the two are distributed, one to each future gamete. This requires that meiosis I chromosomes attach to the spindle differently than meiosis II chromosomes and that they regulate chromosome cohesion differently. We investiga...

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Detalles Bibliográficos
Autores principales: Paliulis, Leocadia V., Nicklas, R. Bruce
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150703/
https://www.ncbi.nlm.nih.gov/pubmed/10995430
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author Paliulis, Leocadia V.
Nicklas, R. Bruce
author_facet Paliulis, Leocadia V.
Nicklas, R. Bruce
author_sort Paliulis, Leocadia V.
collection PubMed
description In meiosis I, two chromatids move to each spindle pole. Then, in meiosis II, the two are distributed, one to each future gamete. This requires that meiosis I chromosomes attach to the spindle differently than meiosis II chromosomes and that they regulate chromosome cohesion differently. We investigated whether the information that dictates the division type of the chromosome comes from the whole cell, the spindle, or the chromosome itself. Also, we determined when chromosomes can switch from meiosis I behavior to meiosis II behavior. We used a micromanipulation needle to fuse grasshopper spermatocytes in meiosis I to spermatocytes in meiosis II, and to move chromosomes from one spindle to the other. Chromosomes placed on spindles of a different meiotic division always behaved as they would have on their native spindle; e.g., a meiosis I chromosome attached to a meiosis II spindle in its normal fashion and sister chromatids moved together to the same spindle pole. We also showed that meiosis I chromosomes become competent meiosis II chromosomes in anaphase of meiosis I, but not before. The patterns for attachment to the spindle and regulation of cohesion are built into the chromosome itself. These results suggest that regulation of chromosome cohesion may be linked to differences in the arrangement of kinetochores in the two meiotic divisions.
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spelling pubmed-21507032008-05-01 The Reduction of Chromosome Number in Meiosis Is Determined by Properties Built into the Chromosomes Paliulis, Leocadia V. Nicklas, R. Bruce J Cell Biol Original Article In meiosis I, two chromatids move to each spindle pole. Then, in meiosis II, the two are distributed, one to each future gamete. This requires that meiosis I chromosomes attach to the spindle differently than meiosis II chromosomes and that they regulate chromosome cohesion differently. We investigated whether the information that dictates the division type of the chromosome comes from the whole cell, the spindle, or the chromosome itself. Also, we determined when chromosomes can switch from meiosis I behavior to meiosis II behavior. We used a micromanipulation needle to fuse grasshopper spermatocytes in meiosis I to spermatocytes in meiosis II, and to move chromosomes from one spindle to the other. Chromosomes placed on spindles of a different meiotic division always behaved as they would have on their native spindle; e.g., a meiosis I chromosome attached to a meiosis II spindle in its normal fashion and sister chromatids moved together to the same spindle pole. We also showed that meiosis I chromosomes become competent meiosis II chromosomes in anaphase of meiosis I, but not before. The patterns for attachment to the spindle and regulation of cohesion are built into the chromosome itself. These results suggest that regulation of chromosome cohesion may be linked to differences in the arrangement of kinetochores in the two meiotic divisions. The Rockefeller University Press 2000-09-18 /pmc/articles/PMC2150703/ /pubmed/10995430 Text en © 2000 The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Original Article
Paliulis, Leocadia V.
Nicklas, R. Bruce
The Reduction of Chromosome Number in Meiosis Is Determined by Properties Built into the Chromosomes
title The Reduction of Chromosome Number in Meiosis Is Determined by Properties Built into the Chromosomes
title_full The Reduction of Chromosome Number in Meiosis Is Determined by Properties Built into the Chromosomes
title_fullStr The Reduction of Chromosome Number in Meiosis Is Determined by Properties Built into the Chromosomes
title_full_unstemmed The Reduction of Chromosome Number in Meiosis Is Determined by Properties Built into the Chromosomes
title_short The Reduction of Chromosome Number in Meiosis Is Determined by Properties Built into the Chromosomes
title_sort reduction of chromosome number in meiosis is determined by properties built into the chromosomes
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150703/
https://www.ncbi.nlm.nih.gov/pubmed/10995430
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