A Novel Function for the Tumor Suppressor p16(INK4a) : Induction of Anoikis via Upregulation of the α(5)β(1) Fibronectin Receptor

The tumor suppressor gene p16(INK4a) inhibits the kinase activity of the cyclin-dependent kinase 4–6/cyclin D complexes and subsequent phosphorylation of critical substrates necessary for transit through the G1 phase of the cell cycle. Recent studies suggested that control of the G1/S boundary might...

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Detalles Bibliográficos
Autores principales: Plath, Thomas, Detjen, Katharina, Welzel, Martina, von Marschall, Zofia, Murphy, Derek, Schirner, Michael, Wiedenmann, Bertram, Rosewicz, Stefan
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150704/
https://www.ncbi.nlm.nih.gov/pubmed/10995450

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