Phosphoinositides and phagocytosis

Phosphoinositide 3 kinases (PI3Ks) are known as regulators of phagocytosis. Recent results demonstrate that class I and III PI3Ks act consecutively in phagosome formation and maturation, and that their respective products, phosphatidylinositol 3,4,5-trisphosphate (PI[3,4,5]P(3)) and phosphatidylinos...

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Detalles Bibliográficos
Autores principales: Gillooly, David J., Simonsen, Anne, Stenmark, Harald
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150801/
https://www.ncbi.nlm.nih.gov/pubmed/11581282
http://dx.doi.org/10.1083/jcb.200109001
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author Gillooly, David J.
Simonsen, Anne
Stenmark, Harald
author_facet Gillooly, David J.
Simonsen, Anne
Stenmark, Harald
author_sort Gillooly, David J.
collection PubMed
description Phosphoinositide 3 kinases (PI3Ks) are known as regulators of phagocytosis. Recent results demonstrate that class I and III PI3Ks act consecutively in phagosome formation and maturation, and that their respective products, phosphatidylinositol 3,4,5-trisphosphate (PI[3,4,5]P(3)) and phosphatidylinositol 3-phosphate (PI[3]P), accumulate transiently at different stages. Phagosomes containing Mycobacterium tuberculosis do not acquire the PI(3)P-binding protein EEA1, which is required for phagosome maturation. This suggests a possible mechanism of how this microorganism evades degradation in phagolysosomes.
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spelling pubmed-21508012008-05-01 Phosphoinositides and phagocytosis Gillooly, David J. Simonsen, Anne Stenmark, Harald J Cell Biol Comment Phosphoinositide 3 kinases (PI3Ks) are known as regulators of phagocytosis. Recent results demonstrate that class I and III PI3Ks act consecutively in phagosome formation and maturation, and that their respective products, phosphatidylinositol 3,4,5-trisphosphate (PI[3,4,5]P(3)) and phosphatidylinositol 3-phosphate (PI[3]P), accumulate transiently at different stages. Phagosomes containing Mycobacterium tuberculosis do not acquire the PI(3)P-binding protein EEA1, which is required for phagosome maturation. This suggests a possible mechanism of how this microorganism evades degradation in phagolysosomes. The Rockefeller University Press 2001-10-01 /pmc/articles/PMC2150801/ /pubmed/11581282 http://dx.doi.org/10.1083/jcb.200109001 Text en Copyright © 2001, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Comment
Gillooly, David J.
Simonsen, Anne
Stenmark, Harald
Phosphoinositides and phagocytosis
title Phosphoinositides and phagocytosis
title_full Phosphoinositides and phagocytosis
title_fullStr Phosphoinositides and phagocytosis
title_full_unstemmed Phosphoinositides and phagocytosis
title_short Phosphoinositides and phagocytosis
title_sort phosphoinositides and phagocytosis
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150801/
https://www.ncbi.nlm.nih.gov/pubmed/11581282
http://dx.doi.org/10.1083/jcb.200109001
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