Where is APC going?

Adenomatous polyposis coli (APC) protein has been thought to function as a tumor suppressor through its involvement in the Wnt/β-catenin signaling pathway. However, its connections to the cytoskeleton and microtubules in particular are becoming apparent, and the discovery of these new functions for...

Descripción completa

Detalles Bibliográficos
Autores principales: Mimori-Kiyosue, Yuko, Tsukita, Shoichiro
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Mini-Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150807/
https://www.ncbi.nlm.nih.gov/pubmed/11564752
http://dx.doi.org/10.1083/jcb.200106113
_version_ 1782144663449239552
author Mimori-Kiyosue, Yuko
Tsukita, Shoichiro
author_facet Mimori-Kiyosue, Yuko
Tsukita, Shoichiro
author_sort Mimori-Kiyosue, Yuko
collection PubMed
description Adenomatous polyposis coli (APC) protein has been thought to function as a tumor suppressor through its involvement in the Wnt/β-catenin signaling pathway. However, its connections to the cytoskeleton and microtubules in particular are becoming apparent, and the discovery of these new functions for APC is leading to a reevaluation of its role not only in tumorigenesis, but also in normal physiology.
format Text
id pubmed-2150807
institution National Center for Biotechnology Information
language English
publishDate 2001
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21508072008-05-01 Where is APC going? Mimori-Kiyosue, Yuko Tsukita, Shoichiro J Cell Biol Mini-Reviews Adenomatous polyposis coli (APC) protein has been thought to function as a tumor suppressor through its involvement in the Wnt/β-catenin signaling pathway. However, its connections to the cytoskeleton and microtubules in particular are becoming apparent, and the discovery of these new functions for APC is leading to a reevaluation of its role not only in tumorigenesis, but also in normal physiology. The Rockefeller University Press 2001-09-17 /pmc/articles/PMC2150807/ /pubmed/11564752 http://dx.doi.org/10.1083/jcb.200106113 Text en Copyright © 2001, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Mini-Reviews
Mimori-Kiyosue, Yuko
Tsukita, Shoichiro
Where is APC going?
title Where is APC going?
title_full Where is APC going?
title_fullStr Where is APC going?
title_full_unstemmed Where is APC going?
title_short Where is APC going?
title_sort where is apc going?
topic Mini-Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150807/
https://www.ncbi.nlm.nih.gov/pubmed/11564752
http://dx.doi.org/10.1083/jcb.200106113
work_keys_str_mv AT mimorikiyosueyuko whereisapcgoing
AT tsukitashoichiro whereisapcgoing

Ejemplares similares