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S-Nitrosylation of mitochondrial caspases

Caspase-3 is a cysteine protease located in both the cytoplasm and mitochondrial intermembrane space that is a central effector of many apoptotic pathways. In resting cells, a subset of caspase-3 zymogens is S-nitrosylated at the active site cysteine, inhibiting enzyme activity. During Fas-induced a...

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Detalles Bibliográficos
Autores principales: Mannick, Joan B., Schonhoff, Christopher, Papeta, Natalia, Ghafourifar, Pedram, Szibor, Marten, Fang, Kezhong, Gaston, Benjamin
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150810/
https://www.ncbi.nlm.nih.gov/pubmed/11551979
http://dx.doi.org/10.1083/jcb.200104008