The tandem C2 domains of synaptotagmin contain redundant Ca(2)+ binding sites that cooperate to engage t-SNAREs and trigger exocytosis

Real-time voltammetry measurements from cracked PC12 cells were used to analyze the role of synaptotagmin–SNARE interactions during Ca(2)+-triggered exocytosis. The isolated C2A domain of synaptotagmin I neither binds SNAREs nor inhibits norepinephrine secretion. In contrast, two C2 domains in tande...

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Detalles Bibliográficos
Autores principales: Earles, Cynthia A., Bai, Jihong, Wang, Ping, Chapman, Edwin R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150817/
https://www.ncbi.nlm.nih.gov/pubmed/11551981
http://dx.doi.org/10.1083/jcb.200105020

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