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Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins

Integrin-mediated adhesion promotes cell survival in vitro, whereas integrin antagonists induce apoptosis of adherent cells in vivo. Here, we demonstrate that cells adherent within a three-dimensional extracellular matrix undergo apoptosis due to expression of unligated integrins, the β subunit cyto...

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Detalles Bibliográficos
Autores principales:	Stupack, Dwayne G., Puente, Xose S., Boutsaboualoy, Souphaphone, Storgard, Chris M., Cheresh, David A.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2001
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150834/ https://www.ncbi.nlm.nih.gov/pubmed/11684710 http://dx.doi.org/10.1083/jcb.200106070

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