Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation

The desmosomal cadherin desmocollin (Dsc)1 is expressed in upper epidermis where strong adhesion is required. To investigate its role in vivo, we have genetically engineered mice with a targeted disruption in the Dsc1 gene. Soon after birth, null mice exhibit flaky skin and a striking punctate epide...

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Detalles Bibliográficos
Autores principales: Chidgey, Martyn, Brakebusch, Cord, Gustafsson, Erika, Cruchley, Alan, Hail, Chris, Kirk, Sarah, Merritt, Anita, North, Alison, Tselepis, Chris, Hewitt, Jane, Byrne, Carolyn, Fassler, Reinhard, Garrod, David
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150874/
https://www.ncbi.nlm.nih.gov/pubmed/11714727
http://dx.doi.org/10.1083/jcb.200105009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150874/
https://www.ncbi.nlm.nih.gov/pubmed/11714727
http://dx.doi.org/10.1083/jcb.200105009

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