The channel of death

The proapoptotic members of the Bcl-2 family have been proposed to participate in the formation of a channel that releases these apoptogenic factors when mitochondria receive apoptotic signals. A recent study provides the first direct, biophysical measurement of a potentially apoptosis-specific mito...

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Detalles Bibliográficos
Autores principales: Degterev, Alexei, Boyce, Michael, Yuan, Junying
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150877/
https://www.ncbi.nlm.nih.gov/pubmed/11724809
http://dx.doi.org/10.1083/jcb.200110147
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author Degterev, Alexei
Boyce, Michael
Yuan, Junying
author_facet Degterev, Alexei
Boyce, Michael
Yuan, Junying
author_sort Degterev, Alexei
collection PubMed
description The proapoptotic members of the Bcl-2 family have been proposed to participate in the formation of a channel that releases these apoptogenic factors when mitochondria receive apoptotic signals. A recent study provides the first direct, biophysical measurement of a potentially apoptosis-specific mitochondrial channel, which is regulated by Bcl-2 family members and may play a primary role in the release of the proapoptotic factors.
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spelling pubmed-21508772008-05-01 The channel of death Degterev, Alexei Boyce, Michael Yuan, Junying J Cell Biol Comment The proapoptotic members of the Bcl-2 family have been proposed to participate in the formation of a channel that releases these apoptogenic factors when mitochondria receive apoptotic signals. A recent study provides the first direct, biophysical measurement of a potentially apoptosis-specific mitochondrial channel, which is regulated by Bcl-2 family members and may play a primary role in the release of the proapoptotic factors. The Rockefeller University Press 2001-11-26 /pmc/articles/PMC2150877/ /pubmed/11724809 http://dx.doi.org/10.1083/jcb.200110147 Text en Copyright © 2001, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Comment
Degterev, Alexei
Boyce, Michael
Yuan, Junying
The channel of death
title The channel of death
title_full The channel of death
title_fullStr The channel of death
title_full_unstemmed The channel of death
title_short The channel of death
title_sort channel of death
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150877/
https://www.ncbi.nlm.nih.gov/pubmed/11724809
http://dx.doi.org/10.1083/jcb.200110147
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