Talin is required for integrin-mediated platelet function in hemostasis and thrombosis

Integrins are critical for hemostasis and thrombosis because they mediate both platelet adhesion and aggregation. Talin is an integrin-binding cytoplasmic adaptor that is a central organizer of focal adhesions, and loss of talin phenocopies integrin deletion in Drosophila. Here, we have examined the...

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Detalles Bibliográficos
Autores principales: Petrich, Brian G., Marchese, Patrizia, Ruggeri, Zaverio M., Spiess, Saskia, Weichert, Rachel A.M., Ye, Feng, Tiedt, Ralph, Skoda, Radek C., Monkley, Susan J., Critchley, David R., Ginsberg, Mark H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150986/
https://www.ncbi.nlm.nih.gov/pubmed/18086863
http://dx.doi.org/10.1084/jem.20071800

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