The structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, an essential enzyme, provides a platform for drug discovery

BACKGROUND: The prevalence of tuberculosis, the prolonged and expensive treatment that this disease requires and an increase in drug resistance indicate an urgent need for new treatments. The 1-deoxy-D-xylulose 5-phosphate pathway of isoprenoid precursor biosynthesis is an attractive chemotherapeuti...

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Detalles Bibliográficos
Autores principales: Buetow, Lori, Brown, Amanda C, Parish, Tanya, Hunter, William N
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151065/
https://www.ncbi.nlm.nih.gov/pubmed/17956607
http://dx.doi.org/10.1186/1472-6807-7-68

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151065/
https://www.ncbi.nlm.nih.gov/pubmed/17956607
http://dx.doi.org/10.1186/1472-6807-7-68

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