N-1 regioselective Michael-type addition of 5-substituted uracils to (2-hydroxyethyl) acrylate

N-1 regioselective Michael-type addition of 5-substituted uracils to (2-hydroxyethyl) acrylate is presented. The reactions were performed in polar aprotic solvents and with avoidance of polymerization of acrylic substrate. The obtained adducts may serve as versatile substrates for further functional...

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Detalles Bibliográficos
Autores principales: Boncel, Sławomir, Osyda, Dominika, Walczak, Krzysztof Z
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2007
Materias:
Preliminary Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151075/
https://www.ncbi.nlm.nih.gov/pubmed/17996035
http://dx.doi.org/10.1186/1860-5397-3-40
Descripción
Sumario:N-1 regioselective Michael-type addition of 5-substituted uracils to (2-hydroxyethyl) acrylate is presented. The reactions were performed in polar aprotic solvents and with avoidance of polymerization of acrylic substrate. The obtained adducts may serve as versatile substrates for further functionalization, e.g. into (3-uracil-1-yl)propanoic acids or transformations, with participation of hydroxyl group, into ester-conjugated acyclic nucleosides.

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