N-1 regioselective Michael-type addition of 5-substituted uracils to (2-hydroxyethyl) acrylate

N-1 regioselective Michael-type addition of 5-substituted uracils to (2-hydroxyethyl) acrylate is presented. The reactions were performed in polar aprotic solvents and with avoidance of polymerization of acrylic substrate. The obtained adducts may serve as versatile substrates for further functional...

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Autores principales: Boncel, Sławomir, Osyda, Dominika, Walczak, Krzysztof Z
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2007
Materias:
Preliminary Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151075/
https://www.ncbi.nlm.nih.gov/pubmed/17996035
http://dx.doi.org/10.1186/1860-5397-3-40
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author Boncel, Sławomir
Osyda, Dominika
Walczak, Krzysztof Z
author_facet Boncel, Sławomir
Osyda, Dominika
Walczak, Krzysztof Z
author_sort Boncel, Sławomir
collection PubMed
description N-1 regioselective Michael-type addition of 5-substituted uracils to (2-hydroxyethyl) acrylate is presented. The reactions were performed in polar aprotic solvents and with avoidance of polymerization of acrylic substrate. The obtained adducts may serve as versatile substrates for further functionalization, e.g. into (3-uracil-1-yl)propanoic acids or transformations, with participation of hydroxyl group, into ester-conjugated acyclic nucleosides.
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spelling pubmed-21510752007-12-21 N-1 regioselective Michael-type addition of 5-substituted uracils to (2-hydroxyethyl) acrylate Boncel, Sławomir Osyda, Dominika Walczak, Krzysztof Z Beilstein J Org Chem Preliminary Communication N-1 regioselective Michael-type addition of 5-substituted uracils to (2-hydroxyethyl) acrylate is presented. The reactions were performed in polar aprotic solvents and with avoidance of polymerization of acrylic substrate. The obtained adducts may serve as versatile substrates for further functionalization, e.g. into (3-uracil-1-yl)propanoic acids or transformations, with participation of hydroxyl group, into ester-conjugated acyclic nucleosides. Beilstein-Institut 2007-11-08 /pmc/articles/PMC2151075/ /pubmed/17996035 http://dx.doi.org/10.1186/1860-5397-3-40 Text en Copyright © 2007, Boncel et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Preliminary Communication
Boncel, Sławomir
Osyda, Dominika
Walczak, Krzysztof Z
N-1 regioselective Michael-type addition of 5-substituted uracils to (2-hydroxyethyl) acrylate
title N-1 regioselective Michael-type addition of 5-substituted uracils to (2-hydroxyethyl) acrylate
title_full N-1 regioselective Michael-type addition of 5-substituted uracils to (2-hydroxyethyl) acrylate
title_fullStr N-1 regioselective Michael-type addition of 5-substituted uracils to (2-hydroxyethyl) acrylate
title_full_unstemmed N-1 regioselective Michael-type addition of 5-substituted uracils to (2-hydroxyethyl) acrylate
title_short N-1 regioselective Michael-type addition of 5-substituted uracils to (2-hydroxyethyl) acrylate
title_sort n-1 regioselective michael-type addition of 5-substituted uracils to (2-hydroxyethyl) acrylate
topic Preliminary Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151075/
https://www.ncbi.nlm.nih.gov/pubmed/17996035
http://dx.doi.org/10.1186/1860-5397-3-40
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AT osydadominika n1regioselectivemichaeltypeadditionof5substituteduracilsto2hydroxyethylacrylate
AT walczakkrzysztofz n1regioselectivemichaeltypeadditionof5substituteduracilsto2hydroxyethylacrylate

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