CPT-11 sensitivity in relation to the expression of P170-glycoprotein and multidrug resistance-associated protein.

The relevance of P170-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) for the sensitivity to CPT-11 was investigated in human malignant cell lines as well as in human tumour xenografts. In vitro, the P-gp-positive sublines BRO/mdr1.1 (transfected with MDR1) and 2780AD were slig...

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Detalles Bibliográficos
Autores principales: Jansen, W. J., Hulscher, T. M., van Ark-Otte, J., Giaccone, G., Pinedo, H. M., Boven, E.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151280/
https://www.ncbi.nlm.nih.gov/pubmed/9472629

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