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Functional Roles of Charged Amino Acid Residues on the Wall of the Cytoplasmic Pore of Kir2.1
It is known that rectification of currents through the inward rectifier K(+) channel (Kir) is mainly due to blockade of the outward current by cytoplasmic Mg(2+) and polyamines. Analyses of the crystal structure of the cytoplasmic region of Kir2.1 have revealed the presence of both negatively (E224,...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2006
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151513/ https://www.ncbi.nlm.nih.gov/pubmed/16533896 http://dx.doi.org/10.1085/jgp.200509434 |