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Na(+) Permeation and Block of hERG Potassium Channels
The inactivation gating of hERG channels is important for the channel function and drug–channel interaction. Whereas hERG channels are highly selective for K(+), we have found that inactivated hERG channels allow Na(+) to permeate in the absence of K(+). This provides a new way to directly monitor a...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2006
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151557/ https://www.ncbi.nlm.nih.gov/pubmed/16769794 http://dx.doi.org/10.1085/jgp.200609500 |