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Regulation of Gating and Rundown of HCN Hyperpolarization-activated Channels by Exogenous and Endogenous PIP(2)

The voltage dependence of activation of the HCN hyperpolarization-activated cation channels is shifted in inside-out patches by −40 to −60 mV relative to activation in intact cells, a phenomenon referred to as rundown. Less than 20 mV of this hyperpolarizing shift can be due to the influence of the...

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Detalles Bibliográficos
Autores principales:	Pian, Phillip, Bucchi, Annalisa, Robinson, Richard B., Siegelbaum, Steven A.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2006
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151583/ https://www.ncbi.nlm.nih.gov/pubmed/17074978 http://dx.doi.org/10.1085/jgp.200609648

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