Phosphoinositide 3-Kinase Binds to TRPV1 and Mediates NGF-stimulated TRPV1 Trafficking to the Plasma Membrane

Sensitization of the pain-transducing ion channel TRPV1 underlies thermal hyperalgesia by proalgesic agents such as nerve growth factor (NGF). The currently accepted model is that the NGF-mediated increase in TRPV1 function during hyperalgesia utilizes activation of phospholipase C (PLC) to cleave P...

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Detalles Bibliográficos
Autores principales: Stein, Alexander T., Ufret-Vincenty, Carmen A., Hua, Li, Santana, Luis F., Gordon, Sharona E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151588/
https://www.ncbi.nlm.nih.gov/pubmed/17074976
http://dx.doi.org/10.1085/jgp.200609576

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151588/
https://www.ncbi.nlm.nih.gov/pubmed/17074976
http://dx.doi.org/10.1085/jgp.200609576

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