Cargando…
Phosphoinositide 3-Kinase Binds to TRPV1 and Mediates NGF-stimulated TRPV1 Trafficking to the Plasma Membrane
Sensitization of the pain-transducing ion channel TRPV1 underlies thermal hyperalgesia by proalgesic agents such as nerve growth factor (NGF). The currently accepted model is that the NGF-mediated increase in TRPV1 function during hyperalgesia utilizes activation of phospholipase C (PLC) to cleave P...
Autores principales: | Stein, Alexander T., Ufret-Vincenty, Carmen A., Hua, Li, Santana, Luis F., Gordon, Sharona E. |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2006
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151588/ https://www.ncbi.nlm.nih.gov/pubmed/17074976 http://dx.doi.org/10.1085/jgp.200609576 |
Ejemplares similares
-
Mechanism for phosphoinositide selectivity and activation of TRPV1 ion channels
por: Ufret-Vincenty, Carmen A., et al.
Publicado: (2015) -
Reciprocal regulation among TRPV1 channels and phosphoinositide 3-kinase in response to nerve growth factor
por: Stratiievska, Anastasiia, et al.
Publicado: (2018) -
Activity and Ca(2+) regulate the mobility of TRPV1 channels in the plasma membrane of sensory neurons
por: Senning, Eric N, et al.
Publicado: (2015) -
Ca(2+)/Calmodulin Modulates TRPV1 Activation by Capsaicin
por: Rosenbaum, Tamara, et al.
Publicado: (2004) -
Interaction with Phosphoinositides Confers Adaptation onto the TRPV1 Pain Receptor
por: Yao, Jing, et al.
Publicado: (2009)