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Phosphomimetic Mutation of Ser-187 of SNAP-25 Increases both Syntaxin Binding and Highly Ca(2+)-sensitive Exocytosis

The phosphorylation targets that mediate the enhancement of exocytosis by PKC are unknown. PKC phosporylates the SNARE protein SNAP-25 at Ser-187. We expressed mutants of SNAP-25 using the Semliki Forest Virus system in bovine adrenal chromaffin cells and then directly measured the Ca(2+) dependence...

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Detalles Bibliográficos
Autores principales:	Yang, Yan, Craig, Tim J., Chen, Xiaohui, Ciufo, Leonora F., Takahashi, Masami, Morgan, Alan, Gillis, Kevin D.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151612/ https://www.ncbi.nlm.nih.gov/pubmed/17325194 http://dx.doi.org/10.1085/jgp.200609685

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